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Clin Med B 2 > Trigger - Interstitial lung disease > Flashcards

Trigger - Interstitial lung disease Flashcards

1
Q

assocaited with accumulation of T lymphocytes, macrophages, and epitheloid cells

A

granulomatous lung disease (ILD)

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2
Q

Fatigue, weight loss, worsening dyspnea, non productive cough

A

symtpoms assocaited with ILD

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3
Q

cachexia, tachypnea, late inspiratory rales, rhonchi

A

ILD

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4
Q

holosystolic tricuspid regurgitation murmur

A

late ILD with pulmonary HTN

may also hear:
loud P2 component of 2nd heart sound
fixed spli S2

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5
Q

what is cor pulmonale

A

the term used to describe RV enlargement, dysfunction and subsequent failure

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6
Q

associated with excessive production and dysregulation of myofibroblasts

A

idiopathic pulmonary fibrosis

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7
Q

MC onset 55 y/o, more male predominant

A

idiopathic pulmonary fibrosis

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8
Q

Which ILDs present with obstructive PFT pattern

A
  • hypersensitivity
  • sarcoidosis
  • complicated diseases (ex. in presence of COPD)
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9
Q

HRCT shows traction bronchiectasis

A

idiopathic pulmonary fibrosis or sarcoidosis

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10
Q

biopsy shows alternating areas of healthy lung, interstitial inflammation, fibrosis, and honeycomb change

A

idiopathic pulmonary fibrosis

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11
Q

nintedanib or pirfenidone are used in treatment for what

A

idiopathic pulmonary fibrosis

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12
Q

what dx is associated with encouragement of patients to apply for clinical trials

A

idiopathic pulmonary fibrosis

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13
Q

tyrosine kinase inhibitor used in IPF

A

nintedanib

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14
Q

anti-inflammatory/antifibrotic agent

A

pirfenidone

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15
Q

CI in liver disease

A

antifibrotics

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16
Q

may be exacerbated by the COVID mRNA vaccine

A

IPF

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17
Q

characterized by the presence of noncaseating granulomas in 2+ organ systems

A

sarcoidosis

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18
Q

MC in african american women and northern europeans

A

sarcoidosis

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19
Q

may see insidious onset of fever, fatigue, night sweats and weight loss

A

sarcoidosis

also dyspnea and cough for 2-4 weeks

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20
Q

presents with conjunctival lesions and scleral plaques

A

sarcoidosis!

also presents with anterior/posterior granulomatous

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21
Q

may lead to blindness if left untreated

A

sarcoidosis

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22
Q

insidious onset of blurred vision, slight photophobia and pain

A

anterior granulomatous uveitis

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23
Q

maculopaper lesions

A

sarcoidosis

also seen:
erythema nodosum
lupus pernio

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24
Q

erythema nodosum

A

sarcoidosis

also see:
lupus pernio
maculopaper lesions

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25
lupus pernio
sarcoidosis also see; maculopaper lesions erythema nodosum
26
painless loss of visual field with scotomas and floaters
posterior granulomatous uveitis
27
can present with hypercalcemia or hypercalciuria
sarcoidosis
28
presents with elevated ESR
sarcoidosis
29
can present with elevated ACE
sarcoidosis
30
assocaited with suppressed PTH
sarcoidosis Granulomas produce 1,25 dihydroxyvitamin D which increases intestinal absorption of Ca - ultimately results in a suppressed PTH
31
what are the things that pulmonary granulomas are known to secrete
1,25 dihydroxyvitamin D ACE
32
CXR with hilar adenopathy and/or infiltrates
sarcoidosis
33
biopsy showing noncaseating granulomas
sarcoidosis
34
increased lymphocytes in bronchoalveolar lavage
sarcoidosis
35
high CD4/CD8 ratio
sarcoidosis
36
what pulmonary disease has cardiac involvement found in 5% of patients
sarcoidosis
37
associated with CXR that shows macules usually 2-5 mm in diameter as well as small <1cm rounded opacities
coal workers pneumoconiosis (uncomplicated) these macules are called coal macules!
38
asymptomatic, minimal changes on PFT, small (<1 cm) rounded opacities on CXR
coal workers pneumoconiosis (uncomplicated)
39
CXR showing nodules ≥1 cm in diameter generally confined to the upper half of the lungs
complicated coal workers pneumoconiosis
40
endobronchial involvement in sarcoidosis would precipitate which PE finding?
wheezing!
41
cough, SOB, pleuritic pain, weight loss, fatigue
acute silicosis (likely complicated)
42
CXR shows small (<10mm) nodules scattered diffusely throughout lungs. more prominent in upper lobes
simple silicosis
43
CXR shows bilateral upper lobe masses formed by coalescence of nodules
complicated silicosis
44
increased risk of TB d/t alveolar macrophage dysfunction
silicosis
45
CXR shows linear opacities, multinodular parenchymal opacities and pleural plaques
asbestosis
46
visceral and parietal plerua are damaged while central portions of the lung are spared in this disease
asbestosis
47
bronchoalveolar lavage showing small rods through macrophages even in patients who are asymptomatic
asbestosis! these rods are called "asbestos bodies"
48
this disease in conjunction with smoking, increases risk of mesothelioma
asbestosis
49
inflammatory pulmonary disease resulting from exposure to inhaled organic antigens leading to an acute illness
hypersensitivity pneumonitis
50
presents as flu like illness (chills, fever, malaise, cough, chest tightness, dyspnea)
acute hypersensitivity pneumonitis
51
onset within hours following exposure of irritant, gradual improvement 12 hours - several days after.
acute hypersensitivity pneumonitis
52
CXR shows a poorly defined micronodular or diffuse interstitial pattern
acute hypersensitivity pneumonitis
53
onset of productive cough, dyspnea, fatigue, anorexia, and weight loss over weeks to months
subacute/chronic hypersensitivity pneumonitis
54
CXR showing progressive fibrotic changes with loss of lung volume and coarse linear opacities
subacute/chronic hypersensitivity
55
what is treated with steroids
* hypersensitivity pneumonitis * sarcoidosis all others are not indicated anymore!
56
insidious onset of dyspnea, intractable dry cough, chest fullness or pain, weakness, and fever
radiation lung disease
57
what three diseases can present with fever?
radiation lung disease sarcoidosis acute hypersensitivity
58
In what disorders are air bronchograms observed in CXR
radiation lung injury
59
CXR shows obliteration of normal lung markings with dense interstitial and pleural fibrosis.
pulmonary radiation fibrosis may also see: reduced lung volumes tenting of the diaphragm sharp delineation of irradiated area
60
CXR showing reduced lung volumes, tenting of the diaphragm and sharp delineation of one area of the lung
pulmonary radiation fibrosis may also see: obliteration of normal lung markings with dense interstitial and pleural fibrosis.

Clin Med B 2 (44 decks)

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