Travel related infections Flashcards
Malaria is an infection caused by_______species.
Name (4) types of these species
what is Malaria? what causes it?
where is it most commonly seen?
which is the most dangerous plasmodial species ? why?
P. falciparum
It can cause a rapidly fulminating disease, characterized by persistent high fever and orthostatic hypotension.
Infection can lead to capillary obstruction and death
plasmodium gets into our blood stream by________, ok, what does it infect then?
female Anopheles mosquitos!
Symptoms of Malaria,
Incubation period? does it differ btw the different types?
Minimum 6 days
P. falciparum: up to 6/12
P. vivax/ovale: up to 1 year+
Malaria Main Diagnostic symptoms
SAC
how does the mosqito first infect the human?
Malaria Investigations (like what tests would u ask for)
Full blood count
Biochemistry:
Urea, Creatinine, Bilirubin, CRP
head CT
chest Xray
Malaria Life cycle
Malaria Treatment
Depends on the Species!
For benign species P. vivax, ovale, malariae
use Chloroquine + primaquine
If resistent
use Mefloquine or Atovaquone
if life threatenting!
P. falciparum (‘malignant’)
Use IV quinidine + doxycycline or artensunate
Prevention of malaria
• Assess risk – knowledge of at risk areas
– Regular/returning travellers
• Bite prevention
– Repellant, adequate clothing, nets
– Chemoprophylaxis before travel
– Must include regular/returning travellers
• Chemoprophylaxis
– Specific to region
– Start before & Continue after return (generally 4 weeks)
which of the 4 types of plasmodium speicies causes the worst infections?
how does it do so?
Plasmodium Falciparum!
>>those infected RBC cant go to the spleen to be destroyed!
Diagnosis of Malaria
P. malariae, P. vivax, & P. ovale cause milder forms of the disease, probably because they invade either young or old red cells, but not both.
This is in contrast to P. falciparum, which invades cells of all ages
which antibiotic is P. Falcipiprum resistence against?
Chloroquine!
it hates the clorophyll queen!
what is an example of a Helminth (worm) and has a life cycle that involves water?
Schistosomiasis !
what type of worm is Schistosomiasis? where is it most commonly found?
flatworm , trpoical areas!
Helminths that cause deep tissue infections include members of all 3 helminth groups: name em
roundworms, tapeworms, and flukes
how do u get helmiths in you? (4)
some by ingestion or penetration of the skin, either by direct entry of the parasites or by insect bites
life cycle of shistomiasis
pretty cool but u dont need to know for the exam tho ;P
shistisoma’s eggs r released by the poop of infected ppl
they hatch when the get into water
they then find a snail and get into their foot trandforing into LARVAE
Larvae gets out of snail and go for a nice swim
u get in the water and its attracted by the FFA in ur skin
it gets in ur blood and goes to liver where it matures into an ADULT worm
goes has sex
lays eggs in your freaking intestinal blood plexus
AAAAND ur fucked ;D
what is Legionella? how is it spread ? what does it do? what can it cause?
(Leigonella Pneaumphilia) is a bacteria that gets into ur upper respiratory tract into your lungs via aerosols or drinking contaminated water,
it gets into ur alveoli & although macrophages engulf it, it CANNOT FUSE with a lysozome, the bacteria multiplies until the phagosome ruptures! releaseing a new family!
It is a less-common cause of pneumonia
name this investigation
The tiny dots reperesent parasites>>in this case malaria
Describe Salmonella Typhi and its virulence factors! how does it invade?
Aerobic gram - rod
A,B,C
fimbrae>> adhere to epithelial surface
Invasins>> allows intracellular growth!
causes disease by attaching to and invading macrophages of the intestinal lymphoid tissue (Peyer’s patches). The bacteria replicate rapidly within these cells,and eventually spread to the reticuloendothelial system (including both liver and spleen, which become enlarged)
what r manifestations of typoid fever?
Rose spots on abdomen
Constipation (or diharrea)
Abdominol pain
fever
low HR
dry cough
maculopapular rash on the trunk (termed “rose spots”)
what has happened here?
Zika virus infection during pregnancy is a cause of microcephaly.
Arbovirus (flavivirus) – Aedes mosquito
what is EBOLA?
symptoms?
spread?
Filo virus >> first described in congo
(Filooooha yala 3ad, baboool)
Flu-like illness w/ vomitting, diarrhoea, headche, confusion, rash
i_nternal and external bleeding_!! at 5-7 days
By direct cotact w/ body fluids!
what is MERS-Cov?
a coronavirus known to ayse severe repiratory illnes!
