Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Infection-alaa > Adaptive response > Flashcards

Adaptive response Flashcards

1
Q

describe features of APC

A

Strategic location (B and T cell interaction)
- Skin (SALT)
- Mucous membranes (GALT, NALT, BALT, GUALT)
- Lymphoid organs (Lymph nodes, spleen)
- Blood circulation (plasmacytoid and myeloid DCs)
What do they do?

• Pathogen capture

  • Phagocytosis (whole microbe)
  • Macropinocytosis (soluble particles)

• Diversity in pathogen sensors (PRRs)

  • Extracellular pathogens (bacteria)
  • Intracellular pathogens (viruses)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

describe MHC molecules in relation to microbe presentation

A

.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Describe T cells and their role w/ infections

A

.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

descibe B cell and antibody production w/ regards to infection

A

.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

difference btw intracellular and extracellular microbes, give example of a microbe

A

intracellular divide in the cell (virus)

& vice versa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

function of APC

A

Present Microbe to T cells

  • theres an invader in the cell
  • this is how it looks like
  • & i want u to do this response
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how do APC present pathogens to the T cells?

A

1) capture it (via phagocytosis and opsonisation)
2) process it
3) present it to T cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the main strategic location (portal of entry, whereb and t cells interact) of the APC?

A

-MALT ( mucosal membrane associated tissues)

  • TYPES» galt, nalt, balt
  • located in the lamina propria.

-they r aggregates of lymphoid tissue that have b & T cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

function of spleen

A

can generate b & T cell response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

difference btw primary and secondary lymphoid organs

A

Primary> Lymphocytes r generated, produced & educated there

Secondary>b & T cells r settled down there and wait for antigen to come ( chilling zone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

in what ways can APC capture Microbes?

A
  • phagocytosis (whole microbe)

- macropinocytosis ( if it was soluble)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

give 4 different types of APC’s, their location, and what cep they present to

A

dentritic»lymph nodes, musocus membranes, blood&raquo_space;Naïve T cells

langerhans»skin»Naïve T cells

macrophages»vary»Effector T cells

B cells (BCR)» lymph tissues»Effector T cells Naïve T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what r naive t cells?

A

T cells that have not encountered an antigen is called a NAIVE T CELL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what r effector T cells

A

those naive T cells that have been activated by APC.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

how do APC process the antigen?

A

done by a set of proteins called MHC (also called HLA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Major Histocompatibility Complex (MHC) is ALSO called Human Leukocyte Antigen (HLA)

A

ok

17
Q

what r 2 types of responses the adaptive immunity makes?

A

humoral & cell mediated

Extracellular microbes>APC> HUMORAL

Intracellular microbes> APC> cell mediated immunity

18
Q

what r key players in the humoral & cell mediated immunity?

A

HUMORAL
Antibodies
Complement
Phagocytosis

CELL MEDIATED
Cytotoxic T lymphocytes Antibodies
Macrophages

19
Q

Name types of MHC complexes and differentiate btw them

A

MHC I

  • A, B, C
  • TCR & CD8
  • Found on all nucleated cells
  • only present antigens from INTRACELLULAR MICROBES

MHC 2 (2 letters)

  • DP, DQ, DR
  • TCR & CD4
  • Found on dendritic cells, macrophages, B cells (the APC cells)
  • EXTRACELLULAR MICROBES
20
Q

which MHC complex is found on dendritic cells, macrophages, B cells?

A

MHC 2

21
Q

MHC 1 & 2 bind only to PEPTIDE antigens

A

ok

22
Q

which MHC complexes only present antigens from INTRACELLULAR MICROBES

A

MHC 1

23
Q

we have DIVERSE MHC complexes, why?

A

due to

-co-dominence
mama and baba BOTH have the gene

-they r highly polymorphic
each gene has different kinds» INCREASED Diversity

24
Q

Main functions of MHC 1 & 2

A

MHC Class I: present peptides from intracellular microbes

MHC Class II: present peptides from extracellular microbes



25
Q

alaa know the structure of MHC class 1 & 2

A

ok

26
Q

MHC class I recognized by ____T cells

MHC class II recognized by \_\_\_\_T cells

A

MHC class I recognized by CD8+ T cells

 MHC class II recognized by CD4+ T cells

27
Q

A 1st year medical student has contracted the flu virus during an immunology lecture. He has a terrible headache, fever and is coughing a lot.

1) The viral proteins on the airway epithelial cells are present by MHC molecules called HLA-DP, HLA-DQ, HLA-DR.
True or false?

2) His dendritic cells will also express the viral peptides
True or false?


A

1) F

2) T

28
Q

virus r presented by MHC class____

A

1

29
Q

how does streptokinase work?

A

dissolves clots through conversion of plasminogen to plasmin

30
Q

functions of the antibodies?

A

notes

Infection-alaa (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions