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MY COMLEX - IMMUNO > Transplant rejection > Flashcards

Transplant rejection Flashcards

1
Q

Hyperacute

A

Within minutes

*type II hypersensitivity reaction

activate complement

Widespread thrombosis of graft vessels–>ischemia/necrosis

Graft must be removed

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2
Q

Acute

A

Weeks to months

*type IV hypersensitivity reaction

Vasculitis of graft vessels with
dense interstitial lymphocytic
infiltrate

Prevent/reverse with
immunosuppressants

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3
Q

Chronic

A

Months to years

*type II and IV
hypersensitivity reactions

Dominated by arteriosclerosis

*Bronchiolitis obliterans (lung)
ƒ*Accelerated atherosclerosis
(heart)
ƒ*Chronic graft nephropathy
(kidney)
ƒ*Vanishing bile duct
syndrome (liver)
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4
Q

Graft-versus-host disease

A

Time Varies

Type IV hypersensitivity reaction

Maculopapular rash, jaundice,
diarrhea, hepatosplenomegaly.

Usually in bone marrow and
liver transplants (rich in
lymphocytes)

Potentially beneficial in bone marrow transplant for leukemia (graft-versus-tumor effect)

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MY COMLEX - IMMUNO (18 decks)

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