T cell Types

Question 1

Th1

Answer 1

Differentiation induced by IFN-γ and IL-12

Secretes IFN-γ

Activates macrophages and cytotoxic T cells

helps B-cells class switch IgM–>IgG

Inhibited by IL-4 and IL-10 (from Th2 cell)

Question 2

Th2

Answer 2

Differentiation induced by IL-4

Secretes IL-4, IL-5, IL-10, IL-13

Recruits eosinophils for parasite defense and
promotes *IgE production by B cells

Inhibited by IFN-γ (from Th1 cell)

Th2=”achooo”

Question 3

Th17

Answer 3

Differentiation induced by TGF-B and IL-6

caused inflammation

Question 4

Treg

Answer 4

Differentiation induced by TGF-B

inhibits all T-cells

produce anti-inflammatory cytokines (eg, IL-10, TGF-β).

Identified by expression of CD3, CD4, CD25, and FOXP3