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MY COMLEX - IMMUNO > PATH - Complement disorders > Flashcards

PATH - Complement disorders Flashcards

1
Q

C1 esterase inhibitor deficiency

A

Causes hereditary angioedema due to unregulated activation of *kallikrein–>INC bradykinin

ACE inhibitors are contraindicated

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2
Q

C3 deficiency

A

Increases risk of severe, recurrent pyogenic sinus and respiratory tract infections

susceptibility to *type III hypersensitivity reactions

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3
Q

C5–C9 deficiencies

A

Terminal complement deficiency INC susceptibility to recurrent *Neisseria bacteremia

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4
Q

DAF (GPI-anchored enzyme) deficiency

A

Causes complement-mediated lysis of RBCs and *paroxysmal nocturnal hemoglobinuria

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MY COMLEX - IMMUNO (18 decks)

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