Autoantibodies

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin, lupus anticoagulant

Answer 3

SLE, antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

Limited scleroderma (CREST syndrome)

Question 5

Anti-desmoglein (anti-desmosome)

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA, anti-Smith

Answer 6

SLE

Question 7

Anti-glutamic acid decarboxylase (GAD-65)

Answer 7

Type 1 diabetes mellitus

Question 8

Anti-hemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Anti-histone

Answer 9

Drug-induced lupus

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Antimicrosomal, antithyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Antimitochondrial

Answer 12

1° biliary cirrhosis

Question 13

Antinuclear (ANA)

Answer 13

SLE, nonspecific

Question 14

Antiparietal cell

Answer 14

Pernicious anemia

Question 15

Antiphospholipase A2 receptor

Answer 15

1° membranous nephropathy

Question 16

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 16

Scleroderma (diffuse)

Question 17

Anti-smooth muscle

Answer 17

Autoimmune hepatitis type 1

Question 18

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 18

Sjögren syndrome

Question 19

Anti-TSH receptor

Answer 19

Graves disease

Question 20

Anti-U1 RNP (ribonucleoprotein)

Answer 20

Mixed connective tissue disease

Question 21

Voltage-gated calcium channel antibodies

Answer 21

Lambert-Eaton syndrome

Question 22

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 22

Celiac disease

Question 23

MPO-ANCA/p-ANCA

Answer 23

*Microscopic polyangiitis
*eosinophilic granulomatosis with polyangiitis (Churg-Strauss
syndrome)

Question 24

PR3-ANCA/c-ANCA

Answer 24

Granulomatosis with polyangiitis (Wegener)

Question 25

Rheumatoid factor (IgM antibody that targets
IgG Fc region), anti-CCP (more specific)

Answer 25

Rheumatoid arthritis