Blood transfusion reactions

Question 1

Allergic reaction

Answer 1

*Type I hypersensitivity reaction against *plasma
proteins in transfused blood.

Urticaria, pruritus, wheezing, fever

Treat with *antihistamines

Question 2

Anaphylactic reaction

Answer 2

Severe allergic reaction

IgA-deficient individuals must receive blood products without IgA.

Dyspnea, bronchospasm, hypotension, respiratory
arrest, shock

Treat with *epinephrine

Question 3

Febrile nonhemolytic transfusion reaction

Answer 3

*Type II hypersensitivity reaction

Host antibodies against donor HLA antigens and
WBCs

Fever, headaches, chills, flushing

Question 4

Acute hemolytic transfusion reaction

Answer 4

*Type II hypersensitivity reaction

Intravascular hemolysis (*ABO blood group incompatibility)
or extravascular hemolysis (host antibody reaction against foreign antigen on donor RBCs).

Fever, hypotension, tachypnea, tachycardia, flank
pain, hemoglobinuria (intravascular hemolysis),
jaundice (extravascular).