Transfusion Reactions Flashcards
Most Common HTR
FNHTR
Second most common HTR
Anaphylaxis
Acute - Immunologic
Acute HTR
hemolysis due to ABO incompatibility
Common cause: Clerical errors
Acute - Immunologic
FNHTR
Antibody to WBC antigen
due to donors WBCs acting with patient anti-HLA antibodies
Acute - Immunologic
Anaphylaxis
seen in IgA deficient individuals
Antibody due to IgA
due to its reaction bet. anti-IgA & IgA transfused product
Acute - Immunologic
Allergy/Urticaria
Antibody to plasma proteins
reaction bet. recipients antibody to transfused donor plasma proteins
Acute - Immunologic
TRALI/Non-cardiac pulmonary edema
Antibody to leukocytes (from donor)
due to donor’s anti-HLA antibody reacting with patient’s leukocytes
Acute - Nonimmunologic effect
TAS/Marked fever with Shock
transfusion associated Sepsis
due to Bacterial Contamination
Most common Bacterial isolate in RBC units
Y. enterolitica (cold resistant)
Followed by* Psudomonas spp.*
S. epedermidis & B. cereus
Most frequently recovered from donated blood & contamination of platelets
Acute - Nonimmunologic
TACO/Congestive Heart Failure
Transfusion associated circulatory overload
Blood Overload
due to rapid infusion of large volume of blood
Acute Transfusion Reactions with Fever
Acute Transfusion Reactions with Fever
* Acute HTR
* FNHTR
* TRALI
* Bacterial Contamination
Acute - Nonimmunologic effect
Hemolysis with symptomps
Blood warmer used >42C
Delayed - Immunologic
Delayed HTR
Hemolysis due to IgG antibodies
common: Rh, second: Kell
Delayed - Immunologic
TA-GVHD
Graft versus host disease
Due to T lymphocyte proliferation
common in immunocomprimised individuals
