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IHBB > Other Major Blood Groups > Flashcards

Other Major Blood Groups Flashcards

1
Q

Lewis Antigens

not a true blood group antigen

A

Plasma Antigens

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2
Q

Associated with CA 19.9

A

Lewis

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3
Q

Gene: lele sese
Phenotype: _______

A

Gene: lele sese
Phenotype: Le(a-b-)

lele individual will not produce any antigen

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4
Q

Gene: Le sese
Phenotype: ________

A

Gene: Le sese
Phenotype: Le(a+b-)

Le determines the expression of Lea

at least one Le gene will be Le (a+)

Lewis gene converts precursor substances to Lea substance

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5
Q

Gene: Le Sese
Phenotype: ________

A

Gene: Le Sese
Phenotype: Le(a-b+)

Se determines expression of Leb

at least one Le and Se gene will be Leb

Se genes converts Lea subtance (Le(a+)) to Leb subtance (Le(b+))

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6
Q

Le(a-b+)

A

Only found in secretion

final blood type of Lewis individual

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7
Q

Lewis Ag development

A

Fetal: Le(a-b-) > 10th day: Le(a+b-) > 10th day to 6th months: Le(a+b+) > Adult:* Le(a-b+)

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8
Q

Leb antigen

A

receptor for H. pylori

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9
Q

Lex

A

marker for Reed-Sternberg cells

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10
Q

Leb is present only if both genes are present:
* __________ gene
* __________ gene

A

Leb is present only if both gene is present:
* Le gene
* Se gene

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11
Q

Lea is present only if ____ genes is present.

A

Le gene

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12
Q

MN Antigens

MN antigens differ in amino acid position 1 & 5

A

Glycophorin A

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13
Q

Ss antigen

Amino acid at position 29

A

Glycophorin B

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14
Q

M Antigen

  • Position 1:
  • Position 5:
A

M Antigen

  • Position 1: Serine
  • Position 5: Glycine
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15
Q

N antigen

  • Position 1:
  • Position 5:
A

N antigen

  • Position 1: Leucine
  • Position 5: Glutamate
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16
Q

Receptor of E. coli

A

M antigen

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17
Q

S antigen AA

amino acid at position 29

A

Methionine

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18
Q

s antigen AA

amino acid at position 29

A

Threonine

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19
Q

Anti-M

IgM

A

React best at ph - 6.5

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20
Q

Anti-M is present in ____________.

A

Anti-M is present in Multiparous women

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21
Q

Anti-N

A

Reacts at alkaline pH

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22
Q

Anti-N are produced by ____ individuals seen in ____________ patients.

A

Anti-N are produced by Nf individuals seen in Dialysis patients.

Nf are altered N antigen by equipment sterilized with Formaldehyde

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23
Q

Iberis amara

A

Anti-M lectin

detects M antigen

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24
Q

Vicia graminea

A

Anti-N lectin

detects N antigen

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25
Q

Glycophorin A and Glycophorin B

A

receptor of P. falciparum

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26
Q

anti-U

A

formed by S-s individuals
common in Blacks

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27
Q

P1

79% of popullation

A

Most common P Ag (79%)

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28
Q

P

A

receptor for Parvovirus B19

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29
Q

P2

A

lacks P1

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30
Q

pnull

A

lacks P1, Pk, and P antigen

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31
Q

Deteriorates rapidly upon storage

A

P1 antigen

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32
Q

P1-like antigens

A

P1-like antigens
* Droppings of pigeons and turtle doves
* Egg white of turtledoves
* Hydatid cyst of E. granulosus

33
Q

P1 susbtsance is identified in ________________ of E. granulosus

A

P1 susbtsance is identified in Hydatid cyst fluid of E. granulosus

Others: extract of lumbricoides terestris & Ascaris suum

34
Q

anti-P1

A

anti-P1
* developed by P2 individuals
* infected with E. granulosus hydatid cyst
* parasitic infection

35
Q

anti-PP1Pk

A

developed by pnull

36
Q

anti-Tja

A

former anti-PP1Pk

37
Q

Ab associated in Spontaneous abortion

A

anti-PP1Pk

38
Q

Ab associated in E. granulosus infection of Hydatid cyst

A

anti-P1

39
Q

autoanti-P

A

associated with PCH

40
Q

Biphasic Antibody

A

autoanti-P

a.k.a Donath Landsteiner Ab

41
Q

Biphasic Ab
* Cold (4C)
* Warm (37C)

A

Biphasic Ab
* Cold (4C) - bind at RBCs
* Warm (37C) - lysis RBCs

42
Q

Associated in P1 individuals with Billiary obstruction & AIHA

A

anti-Pk

43
Q

Found in cord blood cells

A

i antigen

44
Q

I antigens Frequency
* at birth: ____
* 18 months: ____

I is a “public antigen”

A

I antigens Frequency
* at birth: i > I
* 18 months: I > i

45
Q

Nuetralization - I antigen

A

Human milk

46
Q

Autoanti-I

stimulated by microorgamisms with I-like antigens

A

associated in CAS (L. monocytogenes) and PAP (M. pneuomoniae)

47
Q

Associated in Cold Antibody Syndrome (CAS) and Primary Atypical Pneumoniae (PAP)

A

autoanti-I

48
Q

anti-i

A

associated in IM

49
Q

Second to D antigen in terms of immunogenicity

A

Kell

50
Q

Kell Antigen

2

A

2nd most cause of HDFN

51
Q

Kell antigens are destroyed by ________ reagents

A

easily destroyed by SULFHYDRYL reagents

52
Q

Presursor substance of Kell

A

Kx substance

53
Q

Associated Conditions - Kx is absent in RBCs

A

Mcleod Phenotype

54
Q

Associated Conditions - Kx is absent in WBCs

A

Chronic Granulomatous Disease

55
Q

McLeod Phenotype clinical manifestations

A

Acanthocytosis
Neurological & Muscular abnormalities
Compensated Hemolytic Anemia

56
Q

Acanthocytes

A

Mycleod Phenotype

57
Q

Kell incompatibility may develop anti-K as high as _%

A

Kell incompatibility may develop anti-K as high as 10%

58
Q

Fya & Fyb

A

receptor of P. vivax and P. knowlesi

59
Q

Fya

A

more immunogenic

60
Q

Fyb

A

destroyed by enzyme treatment

61
Q

F3

A

RBCs that are Fy(a-b-)

62
Q

Fy (a-b-)

A

associated with resitance to P. vivax in African-american population

63
Q

Fy (a+b-)

A

common in Asian/Chinese (90.8%) population

64
Q

Jk (a-b-)

Jk null phenotype

A

Common allelle in Polynesians, Filipino and Chinese

65
Q

Resist lysis to 2M Urea

A

Jk (a-b-)

66
Q

Most NOTORIOUS antibody

A

Anti-Jka and Anti-Jkb

antibody is not easily detected and disappear rapidly

67
Q

Anti-Jk3

A

produced by Jk null phenotype

68
Q

Complement dependent Antibody

A

Kidd antibodies

anti-Jka & anti-Jkb

69
Q

Anti-Lua

not clinically significant

A

demonstrate a characteristic of “loose mf agglutination pattern”

produced by Lu (a-b-)

70
Q

Anti-Lub

A

Rare & Incomplete antibody
Clinically significant (IgG)

71
Q

Lu (a-b+)

A

Common phenotype in Whites & Blacks

72
Q

Public Antigen

A

High Incidence

73
Q

Knops null phenotype

A

Hagelson

74
Q

Decreased expression in pregnant women

A

Lewis

75
Q

Decreased expression in pregnant women

A

Lewis

76
Q

Lewis are produced in ___________

A

Tissues cells

77
Q

Individuals forming Anti-U

A

S-s- individuals

78
Q

Associated in Rare i Adult

A

HEMPAS or Chronic dsyerythropoietic anemia type 2

79
Q

Found in population of Melanesians and Yanomama indians

A

Anti-It

IHBB (11 decks)

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