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Other Major Blood Groups Flashcards

1
Q

Lewis Antigens

not a true blood group antigen

A

Plasma Antigens

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2
Q

Associated with CA 19.9

A

Lewis

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3
Q

Gene: lele sese
Phenotype: _______

A

Gene: lele sese
Phenotype: Le(a-b-)

lele individual will not produce any antigen

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4
Q

Gene: Le sese
Phenotype: ________

A

Gene: Le sese
Phenotype: Le(a+b-)

Le determines the expression of Lea

at least one Le gene will be Le (a+)

Lewis gene converts precursor substances to Lea substance

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5
Q

Gene: Le Sese
Phenotype: ________

A

Gene: Le Sese
Phenotype: Le(a-b+)

Se determines expression of Leb

at least one Le and Se gene will be Leb

Se genes converts Lea subtance (Le(a+)) to Leb subtance (Le(b+))

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6
Q

Le(a-b+)

A

Only found in secretion

final blood type of Lewis individual

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7
Q

Lewis Ag development

A

Fetal: Le(a-b-) > 10th day: Le(a+b-) > 10th day to 6th months: Le(a+b+) > Adult:* Le(a-b+)

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8
Q

Leb antigen

A

receptor for H. pylori

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9
Q

Lex

A

marker for Reed-Sternberg cells

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10
Q

Leb is present only if both genes are present:
* __________ gene
* __________ gene

A

Leb is present only if both gene is present:
* Le gene
* Se gene

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11
Q

Lea is present only if ____ genes is present.

A

Le gene

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12
Q

MN Antigens

MN antigens differ in amino acid position 1 & 5

A

Glycophorin A

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13
Q

Ss antigen

Amino acid at position 29

A

Glycophorin B

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14
Q

M Antigen

  • Position 1:
  • Position 5:
A

M Antigen

  • Position 1: Serine
  • Position 5: Glycine
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15
Q

N antigen

  • Position 1:
  • Position 5:
A

N antigen

  • Position 1: Leucine
  • Position 5: Glutamate
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16
Q

Receptor of E. coli

A

M antigen

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17
Q

S antigen AA

amino acid at position 29

A

Methionine

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18
Q

s antigen AA

amino acid at position 29

A

Threonine

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19
Q

Anti-M

IgM

A

React best at ph - 6.5

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20
Q

Anti-M is present in ____________.

A

Anti-M is present in Multiparous women

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21
Q

Anti-N

A

Reacts at alkaline pH

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22
Q

Anti-N are produced by ____ individuals seen in ____________ patients.

A

Anti-N are produced by Nf individuals seen in Dialysis patients.

Nf are altered N antigen by equipment sterilized with Formaldehyde

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23
Q

Iberis amara

A

Anti-M lectin

detects M antigen

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24
Q

Vicia graminea

A

Anti-N lectin

detects N antigen

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25
Glycophorin A and Glycophorin B
receptor of **P. falciparum**
26
anti-U
formed by *S-s individuals* common in **Blacks**
27
P1 | 79% of popullation
Most common P Ag (79%)
28
P
receptor for Parvovirus B19
29
P2
lacks P1
30
pnull
lacks P1, Pk, and P antigen
31
Deteriorates rapidly upon ***storage***
P1 antigen
32
P1-like antigens
P1-like antigens * Droppings of pigeons and turtle doves * Egg white of turtledoves *** Hydatid cyst of E. granulosus**
33
P1 susbtsance is identified in ________________ of E. granulosus
P1 susbtsance is identified in **Hydatid cyst fluid** of *E. granulosus* | Others: extract of lumbricoides terestris & Ascaris suum
34
anti-P1
anti-P1 * developed by P2 individuals * infected with E. granulosus hydatid cyst * parasitic infection
35
anti-PP1Pk
developed by pnull
36
anti-Tja
former anti-PP1Pk
37
Ab associated in **Spontaneous abortion**
anti-PP1Pk
38
Ab associated in **E. granulosus infection of Hydatid cyst**
anti-P1
39
autoanti-P
associated with PCH
40
Biphasic Antibody
autoanti-P | a.k.a Donath Landsteiner Ab
41
**Biphasic Ab** * Cold (4C) * Warm (37C)
**Biphasic Ab** * Cold (4C) - bind at RBCs * Warm (37C) - lysis RBCs
42
Associated in *P1 individuals* with **Billiary obstruction** & **AIHA**
anti-Pk
43
Found in cord blood cells
i antigen
44
I antigens Frequency * at birth: ____ * 18 months: ____ | I is a "public antigen"
I antigens Frequency * at birth: i > I * 18 months: I > i
45
Nuetralization - I antigen
Human milk
46
Autoanti-I | stimulated by microorgamisms with I-like antigens
associated in CAS (L. monocytogenes) and PAP (M. pneuomoniae)
47
Associated in Cold Antibody Syndrome (CAS) and Primary Atypical Pneumoniae (PAP)
autoanti-I
48
anti-i
associated in IM
49
Second to D antigen in terms of immunogenicity
Kell
50
Kell Antigen ## Footnote 2
2nd most cause of HDFN
51
Kell antigens are destroyed by ________ reagents
easily destroyed by **SULFHYDRYL** reagents
52
Presursor substance of Kell
Kx substance
53
Associated Conditions - Kx is absent in **RBCs**
**Mcleod Phenotype**
54
Associated Conditions - Kx is absent in **WBCs**
**Chronic Granulomatous Disease**
55
McLeod Phenotype clinical manifestations
Acanthocytosis Neurological & Muscular abnormalities Compensated Hemolytic Anemia
56
Acanthocytes
Mycleod Phenotype
57
Kell incompatibility may develop anti-K as high as **_%**
Kell incompatibility may develop anti-K as high as **10%**
58
Fya & Fyb
receptor of *P. vivax* and *P. knowlesi*
59
Fya
more immunogenic
60
Fyb
destroyed by enzyme treatment
61
F3
RBCs that are Fy(a-b-)
62
Fy (a-b-)
associated with resitance to P. vivax in African-american population
63
Fy (a+b-)
common in Asian/Chinese (90.8%) population
64
Jk (a-b-) | Jk null phenotype
Common allelle in **Polynesians, Filipino and Chinese**
65
Resist lysis to 2M Urea
Jk (a-b-)
66
Most NOTORIOUS antibody
Anti-Jka and Anti-Jkb | antibody is not easily detected and disappear rapidly
67
Anti-Jk3
produced by Jk null phenotype
68
Complement dependent Antibody
Kidd antibodies | anti-Jka & anti-Jkb
69
Anti-Lua | not clinically significant
demonstrate a characteristic of **"loose mf agglutination pattern"** | produced by Lu (a-b-)
70
Anti-Lub
Rare & Incomplete antibody Clinically significant (IgG)
71
Lu (a-b+)
Common phenotype in Whites & Blacks
72
Public Antigen
High Incidence
73
Knops null phenotype
Hagelson
74
Decreased expression in pregnant women
Lewis
75
Decreased expression in pregnant women
Lewis
76
Lewis are produced in ___________
Tissues cells
77
Individuals forming Anti-U
**S-s- individuals**
78
Associated in Rare i Adult
HEMPAS or Chronic dsyerythropoietic anemia type 2
79
Found in population of Melanesians and Yanomama indians
Anti-It

IHBB (11 decks)

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