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IHBB > Rh Blood Group > Flashcards

Rh Blood Group Flashcards

1
Q

Codes for RHD and RHCE genes

A

Chromosome 1

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2
Q

Frequency of Antigens:

D antigen: ___%
d antigen: ___%

A

Frequency of Antigens:

D antigen: 85%
d antigen: 15%

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3
Q

Fischer Race Nomenclature

A

Based of DCE genes (DCE)

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4
Q

Weiner

A

Based on agglutinogen that contain a series of blood factor (Rh-hr)

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5
Q

Rosenfield

A

No genetic basis.
Based on Numerical terms

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6
Q

RHAG

A

gene that codes for Rh associated glycoprotein

Rh precursor substance - coexpressor and express RhD proteins

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7
Q

RhD presursor substance

A

RhAG

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8
Q

R1r

A

Most common phenotypes of Whites

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9
Q

R0r

A

Most common phenotype of Blacks

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10
Q

Phenotype with MOST to LEAST amount of D antigen

A

D– > R2R2 > R1R1 > R1r/R0r > R1r’ or R0r’

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11
Q

R2R2

A

Commonly encountered genotype with high amount of D antigen

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12
Q

Immunogenicity of Rh Ag

A

D > c > E > C > e

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13
Q

Asian Phenotypes

A

R1 > R2 > r > R0

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14
Q

Black Phenotypes

A

R0 > r > R1 > R2

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15
Q

Rh antigens Position and Enzymes - C/c

A

103rd position

Serine - C
Proline - c

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16
Q

Rh antigens Position and Enzymes - E/e

A

226th position

Proline - E
Alanine - e

17
Q

D antigen is immunogenic when exposed to ____ mL of blood.

A

<0.1 ml of blood

18
Q

Weak D

A

Complete but few in numbers

19
Q

Partial D/D Mosaic

A

Incomplete or Missing D antigen ( RHD – RHCE – RHD)

20
Q

RhD positive individual that develops anti-D is present in a _______________ individual.

A

Partial D/D Mosaic

forms anti-D directed towards the missing portion/epitope of the D Ag

21
Q

Partial D individual as a Patient is typed as _________ .

A

Rh negative

to prevent formation of anti-D once exposed to a complete RhD antigen

22
Q

Partial D individual as a Donor is typed as _________ .

A

Rh Positive

23
Q

Del

A

RBCs with extremely low numbers of D antigen

24
Q

Test for Weak D Testing

A

IAT

25
Q

Forms anti-Rh17 if exposed to normal cells

A

D–

26
Q

Forms Rh29

A

Rh null phenotype

27
Q

Rhnull RBC

A

Stomatocytosis

28
Q

Rhmod

A

Partial suppression of Rh gene expression

29
Q

Rh Ab

A

IgG (IgG1 and IgG3)

30
Q

Weak D is common in ________.

A

Blacks

31
Q

Rhnull is common in _______.

A

European

32
Q

Warm autoantibodies appear to have “____________” specificity

A

Warm autoantibodies appear to have “anti-e” specificity

33
Q

Rh null phenotype Diagnosis

A

Rh null phenotype Diagnosis
* Mild compensated Hemolytic Anemia
* Reticulocytosis
* Slight-decrease in Hb and Hct
* Increase HbF
* Decrease Serum Haptoglobin
* Increase Bilirubin
* Stomatocytosis*

IHBB (11 decks)

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