Transfusion Flashcards
1
Q
What two independent variables contribute to TACO?
A
1) Volume of transfusion
2) Rate of transfusion
2
Q
Why does hyperventilation promote citrate toxicity?
A
Causes a decrease in ionized calcium
3
Q
How does citrate exert anticoagulant effects?
A
Binds calcium
4
Q
Why can metabolic alkalosis develop with massive transfusion?
A
Citrate is metabolized to bicarbonate
5
Q
What risk factors increase the risk of citrate toxicity?
A
1) Large transfusions
2) Pediatric patients
3) Liver disease
4) Liver transplantation
5) Hypothermia
6) Hyperventilation
6
Q
What does FFP contain?
A
1) Citrate
2) All clotting factors
3) Fibrinogen
4) Plasma proteins (albumin)
5) Physiologic anticoagulants (Protein C/S and antithrombin)
6) Electrolytes
