transcription 4 Flashcards
what determines and gene being switched on and off
transcription factor binding
what kind of structure do transcription factors do and what do the two sections do
it has a modular structure
- dna binding site
-other components binding site
what are the three components of dna binding domains
zinc fingers
helix turn helix
basic binding domains
what is another name for a helix turn helix and which domain interacts with the dna
homeodomain
helix 3
how do basic charged binding domains bind to dna
they have to dimerise
what binds the basic charge dna binding domains
leucine zipper proteins
what are the different types of activation domains
what tfs interact with the TFIID TAFs
use tfs and enhancer tfs
what allows chromatin to be unwrapped specifically and how does this happen
histone acetylase
neutralises the pos charge of the histone
what do transcription factors recruit to unwrap chromatin
co-activator
what is an inhibitory domain
a domain that allows genes to be switched off and transcription to stop
what two ways does the inhibitory domain get in the way
binds to dna
binds to the PIC
what do inhibitory domains recruit
co-repressors
what specifically do inhibitory regions use to modify histones and what does it do
histone de-acetylase
restores the positive charge of histone
