tranlecture6 Flashcards
tell me about ephedrine
it is the first orally active sympathomimetic drug. Is a mild CNS stimulant, banned in the US.
tell me about amphetamine
related to NE and will force NE out of the vesicle into the cytosal and then forces it out making more NE in the in the synaptic cleft. Stimulates the respiratory center keeps people awake and reduces apatite. Increased heart rate and BP. Increases sphinter contraction used for incontinance.
tell me about tyramine
used to synthesize NE and EPI via alternative pathways raises BP found in fermented cheeses
Tell me about prazosin and is it reversible
much greater for A1 than A2 and its reversible, used for hypertension benign prostate hypertrophy can cause ortho hypotension
tell me about phenoxybezamine
greater a1 over a2 but not as much and irreversible inhibition long duration, also blocks H1 acetylcholine and serotonin used in pheochromocytoma
what are the effects of alpha 1 blockers
lowers blood pressure ortho hypotension, tachycardia, miosis nasal stuffiness, decreased urine flow,
what are the therapeutic uses of alpha 1 blockers
pheochromocytoma, hypertensive emergency, chronic hypertension, peripheral vascular disease, urinary obstruction, erectile dysfunction.
tell me about tamsulosin
blocks A1 used for prostate hyperplasia
tell me about labetalol
blocks Beta and Alpha 1 lowersBp and limited Hr increase due to reflex tachy,
tell me about propranolol
non selective inhibits Beta 1and 2, careful with asthma because of bronchi-constriction,
tell me about metoprolol
more selective for beta 1 over beta 2
tell me about labetalol
equal beta 1 and 2 but greater than alpha1 and more alpha 2
tell me about beta blockers
used for hyperthyroidism, decreased heart rate heart output decreased renin release, increased airway resistance because of blocking beta 2, decreased aqueous humor production and intracranial pressure, inhibits lipolysis,may decrease glucagon release, increased VLDL and lower HDL.
what are the uses of beta blockers
hypertension, ischemic heart disease, cardiac arrhythmia, heart failure to counter long term sympathetic activation leading to less receptors low dose of this will increase the number of receptors, glaucoma, hyperthyroidism, neurological diseases migraines.
what are the important properties for the choice of Beta blockers
cardioselectivity only beta 1 or beta 2 as well, know what the intrinsic sympathomimetic activity they still will have sympathetic effect, lipid solubility if its not lipid soluble it wont go through the hepatic system.
