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CRRAB II > Trachte Diuretics > Flashcards

Trachte Diuretics Flashcards

1
Q

Two drugs that inhibit NKCC pump?

A

Furosemide

Bumetanide

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2
Q

Where is the NKCC pump?

A

Thick ascending loop of henle

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3
Q

How does the NKCC pump affect tubular fluid osmolality?

A

makes it hyPO-osmolar

**no aquaporins in thick ascending loop

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4
Q

Uses for loop diuretics?

A

pulm edema

edema

hyperkalemia

acute renal failure

anion OD

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5
Q

Chlorthalidone?

MOA

A

Blocks NaCl transporter in distal convoluted tubule

**a thiazide diuretic

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6
Q

HCTZ?

MOA

A

Blocks NaCl transporter in distal convoluted tuble

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7
Q

Metalazone?

MOA

A

Blocks NaCl transporter in distal convoluted tubule

thiazide diuretic

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8
Q

Thiazides used to treat?

A

HTN

CHF

nephrolithiasis caused by hypercalcemia

nephrogenic diabetes insipidus

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9
Q

Major side effect of Thiazides?

A

Hyperglycemia
-suppress insulin release

hypOkalemia

HLD

hypOnatremia

allergic RXN

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10
Q

What happens with thiazide + ACE inhib?

A

SYNERGY

RAAS perpetuation??

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11
Q

3 K sparing diuretics?

A

Spironolactone

Amiloride

Triamterene

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12
Q

ADH analogs (2)?

What do they do?

A

Vasopressin

desmopressin (synthetic)

recruit aquaporins in the medulla

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13
Q

Demecocycline?

A

antibiotic with ADH antagonism

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14
Q

Where does ADH originate?

A

hypothalamus/pituitary

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15
Q

What stimulates ADH release?

A

reduction in plasma volume

increase in plasma osmolality

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16
Q

What receptors are stimulated by ADH?

A

AVPR1–PI3/Ca–>vasoconstriction

AVPR2–cAMP–>insert aquaporins

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17
Q

Major osmotic diuretic not reabsorbed into the nephron:

18
Q

What is SGLT-2? Where is it?

A

sodium glucose transporter

proximal tubule

19
Q

3 SGLT-2 transporter inhibitors:

A

“flozins”

Canigliflozin

Dapagliflozin

Gliflozin

20
Q

Carbonic anhydrase inhibitor:

A

acetazolamide

blocks conversion of H2CO3 –> H20+CO2

21
Q

Xanthine oxidase inhibitor?

A

allopurinol

reduces uric acid

22
Q

Inhibit renal organic acid transporters (OATs) of urate to facilitate excretion (2):

A

Probenicid

Sulfinpyrazone

**proximal tubule

23
Q

Net effect of thiazide diuretics on OATs?

A

increase blood uric acid

24
Q

Actual channel blocked by Amiloride and Triamterene?

25
Q

Used to acidify urine?

A

Ammonium Chloride

26
Q

Another drug for gout?

A

colchicine

27
Q

Furosemide?

A

loop diuretic

28
Q

bumetanide

A

loop diuretic

29
Q

chlorthalidone

A

thiazide diuretic

30
Q

hydrochlorothiazide

A

thiazide diuretic

31
Q

metalozone

A

thiazide diuretic

32
Q

spironolactone

A

Blocks Aldosterone receptor

K sparring diuretic

33
Q

Amiloride

A

blocks ENaC

K sparring diuretic

34
Q

Triamterene

A

blocks ENaC

K sparring diuretic

35
Q

Antidiuretic hormone

A

increases aquaporin channels in collecting duct

concentrates urine

36
Q

desmopressin

A

increases aquaporin channels in collecting duct

concentrates urine

37
Q

Mannitol

A

exerts osmotic effect in proximal tubule to reduce water reabsorption

38
Q

“flozins”

A

SGLT-2 inhibitors

reduce glucose reabsorption

39
Q

Acetazolomide

A

carbonic anhydrase inhibitor

blocks reabsorption in prox tubule

**mostly used for glaucoma and excess CSF production

40
Q

probenicid

A

suppresses urate reabsorption in the proximal tubule

41
Q

sulfinpyrazone

A

suppresses urate reabsorption in the proximal tubule

42
Q

allopurinol

A

suppresses uric acid formation

CRRAB II (28 decks)

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