Asthma/PE PBL Drugs

Question 1

1st Gen H1 antagonists (2)

cross BBB

**some anti-muscarinic effects

Answer 1

diphenhydramine

chlorpheniramine

Question 2

2nd Gen H1 antagonists (3)

substrate for P-glycoprotein (actively pumped out of BBB)

Answer 2

fexofenadine

cetirizine

loratidine

Question 3

Methylxanthine (similar to caffeine)

may be bronchodilatory

narrow therapeutic index

Answer 3

theophylline

Question 4

Stabilizes Mast cells –> no degranulation

Answer 4

cromolyn sodium

Question 5

non-selective adrenoreceptor agonist

B1, B2, a1

Answer 5

epinephrine

Question 6

short acting beta-2 agonist

tolerance may develop w overuse (downregulation of B2’s)

Answer 6

albuterol

Question 7

long acting B2 agonist

toleance me develop w overuse

Answer 7

salmeterol

Question 8

5-lipoxygenase inhibitor –> prevents leukotriene synthesis

**hepatotoxicity

Answer 8

zileuton

Question 9

2 leukotriene receptor antogonists

Answer 9

zafirlukast

montelukast

Question 10

Alpha-1 agonist

Answer 10

phenylephrine

Question 11

a-1, a-2 agonist

Answer 11

pseudoephedrine

Question 12

induce lipocortin to inhibit phospholipase A2 –> inhibits synthesis of cytokines

Answer 12

corticosteroids

betamethasone
dexamethasone
methylprednisolone
prednisone
triamcinolone
beclamethasone

Question 13

binds circulating IgE and prevents it binding to mast cells and basophils

Answer 13

omalizumab

Question 14

flunisolide

Answer 14

glucocorticoid receptor agonist

inhaled

Question 15

budesonide

Answer 15

inhaled glucocorticosteroid

Question 16

fluticasone

Answer 16

synthetic glucocorticosteroid

Question 17

formoterol

Answer 17

long acting beta-2 agonist

Question 18

pirbuterol

Answer 18

short acting B-2 agonist

Question 19

inhibits vit-K dependent clotting factors:

II

VII

IX

X

protein C (inhibited first)

protein S

Answer 19

warfarin

Question 20

increases anti-thrombin activity

decreases thrombin and factor Xa

Answer 20

Heparin

Question 21

Similar to heparin but:

more Xa inhibition

longer half life

Answer 21

LMW heparin:

enoxaparin

dalteparin

Question 22

direct Xa inibitors

Answer 22

apixaban

rivoroxaban

“xa” in the name

Question 23

selective Xa inhibitor VIA anti-thrombin III:

Answer 23

fondaparinux

Question 24

direct thrombin inhibitors (2):

Answer 24

argatroban

bivalirudin

Question 25

stimulates conversion of plasminogen to plasmin….clot buster!

cleavage of fibrin mesh, destruction of coag factors

Answer 25

tPA

Question 26

two drugs that block cys-LT1 receptors inhibiting mast cell and eosinophil activity:

Answer 26

montelukast

zafirlukast