10/23 Renal Path Flashcards
Type of collagen in the GBM?
Type IV
Three layers of GBM:
lamina rara interna
lamina densa
lamina rara externa
Podocyte foot processes interdigitate with which layer of GBM?
lamina rara externa
**they synthesize GBM components
Two slit diaphragm proteins:
nephrin
podocin
Five features of mesangial cells:
- contractile
- phagocytic
- proliferative
- secrete inflammatory mediators
- lay down collagen
Normally minimal insterstitium expands when?
disease states
Typical mechanism of glomerular disease:
immune mediated
Biochemical abnormality of increased BUN/Creatinine?
Azotemia
Azotemia + clinical symptoms:
Uremia
- Hematuria
- mild-moderate proteinuria
- HTN
nephr-i-tic syndrome
- > 3.5 gm/day proteinuria
- edema
- hyperlipidemia
- lipiduria
nephr-O-tic syndrome
Chronic renal failure/chronic kidney disease classification:
GFR
GFR with high risk for CVD?
Pre-renal increase in BUN:
increased synthesis of urea from:
- catabolism (burns, fever, stress)
- high protein diet
- GI bleed
- hemolysis
- malignancy
decrease in renal perfusion/low flow states
- hypotension
- CHF
- dehydration
- renal vein thrombosis
When BUN increases out of proportion to GFR:
decreased renal perfusion
