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CRRAB II > Renal Path 10/28 (lots of Glomerular Nephritis) > Flashcards

Renal Path 10/28 (lots of Glomerular Nephritis) Flashcards

1
Q

Autosomal dominant PCKD?

A

Adult

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2
Q

Berry aneurysms

A

Adult PCKD

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3
Q

Mitral valve prolapse

A

Adult PCKD

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4
Q

Autosomal recessive PCKD?

Enlarged, smooth kidneys

A

Childhood

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5
Q

7% of dialysis patients with acquired cystic develop?

A

renal cell carcinoma

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6
Q

The BIG feature of glomerulonephritis?

A

IMMUNE MEDIATED

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7
Q

complement C5a molecule does what?

A

chemotactic for neutrophils

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8
Q

“Diffuse” GN means:

A

all glomeruli involved

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9
Q

“focal” GN means:

A

a portion of glomeruli involved

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10
Q

“Global” GN means:

A

entire single glomerulus involved

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11
Q

“Segmental” GN means:

A

part of single glomerulus involved

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12
Q

some component of the kidney is the antigen?

A

in situ immune complex deposition

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13
Q

antigens and antibodies form complex before deposit in kidney:

A

circulating immune complex deposition

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14
Q

LINEAR, homogenous, diffuse pattern on IF:

A

Anti-GBM GN

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15
Q

Pulmonary alveoli involvement GN

A

Goodpastures

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16
Q

NC1 domain of alpha 3 chain of type IV collagen is antigen

A

Anti-GBM GN

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17
Q

Granular, interrupted pattern on IF

M-type Phospholipase A2 antigen

A

Membranous GN

Heymann

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18
Q

Inflammatory and Proliferative GN

A

Nephr-I-tic syndrome

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19
Q

Proteinuria > 3.5 g/24 hrs

A

Nephr-O-tic syndrome

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20
Q

Low serum C3

Large hypercellular glomeruli

subEPIthelial “Camel Humps” on EM

A

Acute Poststreptococcal GN

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21
Q

“smoky” urine

periorbital edema

children

A

Acute poststreptococcal GN

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22
Q

Crescents (fibrinous proliferations) of parietal epithelial cells of Bowman’s capsule mixed with inflammatory cells

A

Rapidly Progressive GN

23
Q

RPGN

LINEAR deposits in IF

A

Type I

anti-GBM

24
Q

RPGN

“lumpy-bumpy” granular pattern on IF

A

Type II

Immune complex mediated

25
RPGN lack of IF staining pANCA or cANCA
Type III Pauci-immune
26
Time frame for RPGN
Weeks
27
Complement mediated damage to GBM "SPIKES" on silver stain
Membranous GN
28
Most common cause of nephrotic syndrome in children
Minimal Change Disease
29
Atopy (prone to allergic rxn) Hodgkin Lymphoma
Minimal Change Disease
30
Tx for minimal change disease?
corticosteroids **responds well!!!
31
Diffuse Effacement of Foot Processes and no deposits on EM no IF staining normal glomeruli
Minimal Change Disease
32
Main lab finding in MCD?
MASSIVE proteinuria
33
sclerosis of SOME (not all) gloms HIV HEROIN Sickle cell Morbid Obesity
Focal Segmental Glomerulosclerosis FSGS
34
Pathogenesis of FSGS:
damage to visceral epithelial cells
35
On light microscopy: Collapsed GBM increased mesangial matrix hyalinization +/- foam cells
FSGS
36
proteinaceous material and inflammation tubuloreticular inclusions in endothelial cells
HIV nephropathy
37
leukocyte infiltration mixed nephrotic/nephritic
Membranoproliferative Glomerulonephritis
38
SLE Hep B/C Endocarditis Infx vetriculoarterial shunts Hematologic malignancy
Membranoproliferative Glomerulonephritis
39
"tram track" on silver stain
MPGN
40
SUBENDOTHELIAL deposits on EM Alternative complement pathway
Type I MPGN
41
"Dense deposit disease" | -lamina densa of GBM is "RIBBON LIKE"
Type II MPGN
42
Most common glomerulonephritis worldwide
IgA Nephropathy
43
recurrent hematuria maybe gluten enteropathy or liver disease related
IgA Nephropathy
44
Site of IgA deposition in IgA Nephropathy?
mesangium
45
MESANGIAL DEPOSITS OF IGA ON I.F.
IgA nephropathy
46
Hematuria following respiratory, GI, or urinary tract infx:
IgA nephropathy
47
Nephritis nerve deafness eye disorders
Alport Syndrome
48
Irregular "thick and thin" GBM splitting of lamina densa
Alport Syndrome
49
COL4A5 defective GBM synthesis
Alport Syndrome
50
Diffuse thinning of GBM
Thin Membrane Disease
51
Small, diffusely granular kidneys Globally hyalinized glomeruli
Chronic GN
52
Disease most likely to progress to Chronic GN?
RPGN (crescentic)
53
"Full house" -- IF stains with everything "Wire loop" lesions
Lupus Nephritis
54
IgA in mesangium Purpuritic skin lesions
HSP

CRRAB II (28 decks)

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