11/2 Renal Path Flashcards
Capillary basement membrane thickening
diffuse increase in mesangial matrix
Hyaline masses at glom periphery (Kimmelstiel-Wilson)
Diabetic nephropathy
Initial presentation of diabetic nephropathy:
microalbuminuria
Ischemic or toxic tubular injury:
Acute tubular necrosis
or
acute tubular injury
Inflammatory reaction of tubules and interstitium:
tubulointerstitial nephritis
In addition to inadequate blood flow, what causes ischemic patterns in ATN?
hemolysis
mismatched blood transfusions
skeletal muscle destruction (myoglobin)
Patchy pattern of ATN?
ischemic
contiguous pattern of ATN?
toxic type
Calcium oxalate crystals in tubular lumens?
Ethylene glycol poisoning
PMNs/Eos
Edema
= ________ tubulointerstitial nephritis
acute
fibrosis
tubular atrophy
= __________ tubulointerstitial nephritis
chronic
Neoplasm related to tubulointerstitial nephritis:
multiple myeloma
Most common poles of kidney affected by acute pyelonephritis due to reflux?
upper and lower
Two ways to cause pelvocalyceal damage:
chronic pyelonephritis
analgesic nephropathy
Irregularly scarred surface of kidney:
Chronic pyelonephritis
thyroidization
colloid casts
chronic pyelonephritis
lymphocytes ACUTELY?
Acute DRUG-induced interstitial nephritis
classically seen with chemo?
Urate nephropathy
**precipitation of uric acid crystals in renal tubules
Bence Jones proteins:
Multiple myeloma
Hyaline deposition in arterioles d/t endothelial cell injury
nephrosclerosis
“flea bitten” appearance of kidney
malignant nephrosclerosis
“Onion skinning” of vessels
Malignant nephrosclerosis
BP defining malignant nephrosclerosis:
Diastolic > 120
Renal artery stenosis in young female, think:
fibromuscular dysplasia
75% of classic HUS (hemolytic uremic syndrome) associated with?
E. coli (0157:H7)