11/2 Renal Path

Question 1

Capillary basement membrane thickening

diffuse increase in mesangial matrix

Hyaline masses at glom periphery (Kimmelstiel-Wilson)

Answer 1

Diabetic nephropathy

Question 2

Initial presentation of diabetic nephropathy:

Answer 2

microalbuminuria

Question 3

Ischemic or toxic tubular injury:

Answer 3

Acute tubular necrosis

or

acute tubular injury

Question 4

Inflammatory reaction of tubules and interstitium:

Answer 4

tubulointerstitial nephritis

Question 5

In addition to inadequate blood flow, what causes ischemic patterns in ATN?

Answer 5

hemolysis

mismatched blood transfusions

skeletal muscle destruction (myoglobin)

Question 6

Patchy pattern of ATN?

Answer 6

ischemic

Question 7

contiguous pattern of ATN?

Answer 7

toxic type

Question 8

Calcium oxalate crystals in tubular lumens?

Answer 8

Ethylene glycol poisoning

Question 9

PMNs/Eos

Edema

= ________ tubulointerstitial nephritis

Answer 9

acute

Question 10

fibrosis

tubular atrophy

= __________ tubulointerstitial nephritis

Answer 10

chronic

Question 11

Neoplasm related to tubulointerstitial nephritis:

Answer 11

multiple myeloma

Question 12

Most common poles of kidney affected by acute pyelonephritis due to reflux?

Answer 12

upper and lower

Question 13

Two ways to cause pelvocalyceal damage:

Answer 13

chronic pyelonephritis

analgesic nephropathy

Question 14

Irregularly scarred surface of kidney:

Answer 14

Chronic pyelonephritis

Question 15

thyroidization

colloid casts

Answer 15

chronic pyelonephritis

Question 16

lymphocytes ACUTELY?

Answer 16

Acute DRUG-induced interstitial nephritis

Question 17

classically seen with chemo?

Answer 17

Urate nephropathy

**precipitation of uric acid crystals in renal tubules

Question 18

Bence Jones proteins:

Answer 18

Multiple myeloma

Question 19

Hyaline deposition in arterioles d/t endothelial cell injury

Answer 19

nephrosclerosis

Question 20

“flea bitten” appearance of kidney

Answer 20

malignant nephrosclerosis

Question 21

“Onion skinning” of vessels

Answer 21

Malignant nephrosclerosis

Question 22

BP defining malignant nephrosclerosis:

Answer 22

Diastolic > 120

Question 23

Renal artery stenosis in young female, think:

Answer 23

fibromuscular dysplasia

Question 24

75% of classic HUS (hemolytic uremic syndrome) associated with?

Answer 24

E. coli (0157:H7)

Question 25

Factor H deficiency?

Answer 25

Familial HUS

Question 26

Fever

neurologic sx

MAHA

thrombocytopenia

renal failure

Answer 26

Idiopathic TTP

Question 27

Most common type of kidney stone:

Answer 27

calcium oxalate

calcium phosphate

Question 28

Radiolucent stones

Answer 28

uric acid

Question 29

stones from urea splitting bacteria?

Answer 29

Magnesium Ammonium Phosphate

Question 30

Tumor associated with tuberous sclerosis

Answer 30

Angiomyolipoma

**benign

Question 31

Tumor

Mahogany brown

abundant mitochondria

benign

Answer 31

Oncocytoma

Question 32

Most common renal malignant tumor:

Answer 32

Renal cell carcinoma

Question 33

Von hippel-Lindau syndrome

chromosome 3p25.3

Answer 33

Renal cell carcinoma

Question 34

Bright yellow tumor

Answer 34

renal cell carcinoma

Question 35

renal cell carcinoma w/loss of 3p

Answer 35

clear cell

Question 36

renal cell carcinoma

foam cells

trisomy 7, 17, loss of Y

Answer 36

Papillary

Question 37

renal cell carcinoma

vegetable like cells

Answer 37

chromophobe

Question 38

RCC tends to invade/travel along:

Answer 38

renal vein

Question 39

most common mets for RCC:

Answer 39

lung

bone

Question 40

identical to tumor for in bladder?

Answer 40

Urothelial (transitional cell) carcinoma of the renal pelvis