toxicology Flashcards
ethylene glycol urinary fnding
Ca oxalate crystals
freshly mown grass scent
organophosphates
almond scent
phosgene, arsenic, phosphorus
symmetrical descending muscle weakness + drooling + dysphagia (toxicity)
botulism
arthritis pain + tinnitus med concern
aspirin
when should first level of acetaminophen be drawn after ingestion of unknown amount?
4 hours
toxicity: sympathomimetic agents
cocaine, amphetamines, meth, street drugs
toxicity: cholinergic agents
organophosphate (pesticide, insecticide)
toxicity: anticholinergic agents
jimson weed, atropine
tell-tale sign of opioid toxicity
pinpoint pupils
toxidrome mgmt: key points
ABCsAMS + glucosehyperactivityhtnseizures (benzos)decon
causes of miosis
OpioidsCentral alpha 2 agonistsOrganophosphatesPhencyclidineSedative hypnoticsPhenothiazinesNicotinePilocarpine Opthalmic dropsOlanzapine (Zyprexa)Pontine Hemorrhage
activated charcoal: how much + when to use
1g/kg PO within 2 - 4 hours ingestion
when not to use activated charcoal
P esticidesH ydrocarbonsA lcohol, acids, alkaliI ron preparationsL ithiumS olvents
naloxone (Narcan) doses + half life
10 mgopioids: start ~0.4 and titrate up to wake respiratory drive (may not want to fully awaken d/t agitation)half-life usually ~60-90 min
when to use naloxone (Narcan)
R eserpineO pioidsC lonidineL omotilA CE & ARBV alproic acidA ldometZanaflex
benzo: reversal agent
flumazenil + airway mgmt- rare d/t poss withdrawal seizures (ok if not chronic benzo user)
heparin: reversal agent
protamine - basic vs heparin acidic- also anticoag, don’t give too much
warfarin: reversal agent
vitamin K +/- FFP or PCC- takes 4 to 6 hrs- FFP replenishes other products, PCC as effective
chelating agents, lead or zinc: reversal agent
EDTA or BAL
chelating agents, gold, arsenic, or mercury: reversal agent
BAL or D-penicillamine
med contraindicated in mgmt of meth assoc htn crisis
metoprolol - beta 1 selective blocker = unopposed alpha
causes of gap acidosis
M ethanolU remiaD KAP ropylene GlycolI NH or IngestionL actic AcidosisE thylene GlycolS alicylates
sulfonylurea: reversal agent
octreotide (Sandostatin)
crotalidae snake + toxin
pit viber (rattlesnakes, copperheads, cottonmouths, water moccasin)hemotoxin
elapidae snake + toxin
coral snake: neurotoxin