hemonc

Question 1

leukemia

Answer 1

cancer of marrow + lymph systems
LEUKOCYTE EXPLOSION!

myeloid vs lymphoid, acute or chronic

cure: bone marrow tx

Question 2

leukemia types x2

Answer 2

acute or chronic

myeloid or lymphoid

Question 3

acute myeloid leukemia

Answer 3

cancer of WBC - all immature
inhibits healthy WBC, RBC, and plt

BLASTS! BLASTS! BLASTS!

Question 4

AML poor prognosis

Answer 4

• 50+
• secondary AML (s/t chemo tx)
• genetic mutation

Question 5

AML s/s

Answer 5

fever
fatigue
pallor
ecchymosis
bone pain
infection 
SOB

auer rods, pancytopenia, splenomegaly, hepatomegaly, renal failure

Question 6

acute lymphoid leukemia

Answer 6

rapid T & B in marrow
adults = BCR-ABL + philadelphia genes
tx: in-depth in/out hospital

Question 7

chronic myeloid leukemia

• hallmark
• phases x3

Answer 7

slow growing, diagnosed at PCP office visits

• sx: chronic fatigue
• phases: chronic, accelerated, blast (dep on # blast in bone marrow)

Question 8

lymphoma

Answer 8

cancer of B, T, NK cells
originating in the lymphatic system
- hodgkin vs non

Question 9

hodgkin lymphoma sx/presentation

Answer 9

sx: fever, chill, night sweats, wt loss over mos
pres: large nodes, mediastinal mass

Question 10

hodgkin lymphoma dx

Answer 10

PET (PDG+)

biopsy = Reed Sternberg cells !!!

Question 11

Reed Sternberg cells

Answer 11

characteristic of hodgkin lymphoma

Question 12

non-hodgkin lymphoma

Answer 12

everything else that isn’t hodgkin

tx: CHOP-R

Question 13

multiple myeloma

Answer 13

malignant PLASMA CELLS (B-cells - monoclonal immunoglobulin)

proliferation in bone marrow, if mass occurs outside marrow: plasmacytoma

Question 14

multiple myeloma hallmark sx

Answer 14

bone disease - pain, fractures d/t hypercalcemia bone turnover

also, anemia (marrow is wack)

Question 15

multiple myeloma dx

Answer 15

10+% monoclonal plasma cell in bone marrow
+/- bx: plasmacytoma
monoclona protein in serum or urine

Question 16

multiple myeloma CRAB

Answer 16

organ dysfxn!
C a increased (10.5+)
R enal insufficiency (creat 2+)
A nemia (hgb under 10)
B one lesions (lytic)

Question 17

multiple myeloma types x3

Answer 17

MGUS (likely won’t progress)
smoldering (asx)
plasmacytoma

Question 18

ALL sx

Answer 18

fever
anorexia
bone joint pain
dyspnea
pallor
purpura/petechiae
hepatosplenomegaly

Question 19

CML sx

Answer 19

massive splenomegaly
malaise
fever
wt loss
bone/joint pain
leukocytosis

Question 20

chronic lymphoid leukemia s/s

Answer 20

recurrent infection
malaise
anorexia
fatigue
splenomegaly
bleeding 
lymphocytosis