Toxicology (1-2) Flashcards
name the 3 stages of decontamination
- decrease toxin absorption
- enhance toxin elimination
- general supportive care
name 4 locations where toxins are absorbed
- intestine
- eyes
- stomach
- skin
how to prevent absorption of toxins in the intestines?
charcoal
how to prevent absorption of toxins in the stomach?
emesis; lavage
how to prevent absorption of toxins in the eyes?
flush
how to prevent absorption of toxins in the skin?
wash
name the emetic
stimulates dopamine receptors in chemoreceptor trigger zone (CTZ);
non-selective dopamine receptor agonist;
0.02-0.04 mg/kg IV;
adverse effects: sedation, protracted vomiting
apomorphine
name the emetic
local gastric irritant;
1-2 mL/kg;
adverse effects: protracted vomiting, severe oesophagitis; gastric ulceration;
USA;
not recommended
3% hydrogen peroxide
name the emetic
stimulates dopamine receptors in chemoreceptor trigger zone (CTZ);
selective for dopamine D2-type receptors;
30 mg/mL ophthalmic solution;
adverse effects: mild ocular irritation, ocular discharge, protrusion of 3rd eyelid and blepharospasm
ropinirole
what receptors are rich in the chemoreceptor trigger zone (CTZ) of the dog
dopamine receptors
what receptors are rich in the chemoreceptor trigger zone (CTZ) of the cat
alpha2 receptors
what is the route of admin for emetics in cats
IM
name 2 emetics for cats
- Dexmedetomidine
- Xylazine
name 7 contraindications for emesis
- inability to protect airway
- neurological signs
- sedation
- respiratory distress
- bradycardia
- already vomiting
- with corrosive/caustic toxicants
this is the administration and evacuation of fluid through an orogastric tube;
best within 1-2h of toxin ingestion
gastric lavage
name 5 indications for gastric lavage following toxin ingestion
- failure of emesis
- altered level of consciousness
- admin. of charcoal
- toxicants remaining in stomach
- narrow safety margin
where should you premeasure an orograstric tube to for gastric lavage
to last rib
what is the dose for activated charcoal following toxin ingestion
1-3 g/kg PO
name 3 advere effects of activated charcoal
- vomiting
- dehydration
- hypernatraemia
name 6 substances that are NOT adsorbed by activated charcoal
- heavy metals
- xylitol
- alcohols
- petroleum distillates
- nitrates
- acids/alkalis
how often can activated charcoal be repeated?
every 4-8h