Cardiology (1-9) Flashcards
in canine cardiac cases, what is a cough commonly due to?
left atrial enlargement
is it common for cats to cough with cardiac disease?
no
what clinical sign is commonly seen with congestive heart failure (CHF) in cats and dogs
dyspnoea
dyspnoea is commonly seen in left congestive heart failure (CHF) due to what?
pulmonary oedema
dyspnoea is commonly seen in right congestive heart failure (CHF) due to what?
pleural effusion
what is pleural effusion in cats commonly caused by?
left congestive heart failure (CHF)
what type of activity can prolonged hypoxia cause?
seizure-like activity
what blood test assesses myocardial damage?
troponin-1
what blood test assesses myocardial stretch?
Pro-BNP
name 6 factors that affect the quality of thoracic radiographs
- phase of respiration
- view
- rotation
- exposure factors
- developing
- obesity
what vertebrae do you measure the vertebral heart score (VHS) from?
T4
what should the vertebral heart score be?
less than or equal to 10.5
name 3 types of blood pressure measurements
- direct
- oscillometric
- doppler
name the heart disease
chronic activation of the compensatory systems (RAAS, sympathetic system, vasopressin, endothelin, etc) leads to fluid retention and cardiac remodelling
congestive heart failure (CHF)
name the stage of heart failure - MMVD (myxomatous mitral valve disease)
genetic predisposition but no structural changes
stage A
name the stage of heart failure - MMVD (myxomatous mitral valve disease)
no clinical signs, murmur, no clinically significant cardiomegaly
Stage B1
name the stage of heart failure - MMVD (myxomatous mitral valve disease)
no clinical signs, murmur, cardiomegaly (EPIC)
Stage B2
name the stage of heart failure - MMVD (myxomatous mitral valve disease)
past or current clinical signs of congestive heart failure (CHF)
Stage C
name the stage of heart failure - MMVD (myxomatous mitral valve disease)
severe refractory CHF
Stage D
what drugs can be used to treat heart failure by decreasing preload?
diuretics
(furosemide, torasemide, spironolactone)
name 3 diuretics that can be used to decrease preload
- Furosemide
- Torasemide
- Spironolactone
what drugs can be used to treat heart failure by decreasing afterload?
vasodilators
(ACEi, pimobendan)
name 4 types of vasodilators that can be used to decrease afterload
- ACEi
- inodilators
- nitric oxide donors
- Ca2+ channel blockers
name the 5 step approach to an acute case of left-sided CHF (congestive heart failure)
- oxygen and cage rest
- IV furosemide
- IV pimobendan (licensed for dogs only)
- sedation if distressed
- thoracocentesis (cats)
name the 3 step approach to an acute case of right-sided CHF (congestive heart failure)
- thoracocentesis (dog) if dyspnoeic
- abdominocentesis
- treat underlying cause
what is the standard treatment for a chronic case of congestive heart failure (CHF) in dogs
(4 drugs)
- furosemide
- pimobendan
- ACEi
- Spirinolactone
what is the standard treatment for a chronic case of congestive heart failure (CHF) in cats
(3 parts)
- furosemide
- clopidogrel
- +/- thoracocentesis
name the 3 categories of diuretics
- loop diuretics
- K+ sparing
- hydrochlorthiazies
name the diuretic
potent diuretic;
fast onset of action;
inhibits K+/Na+/2Cl- pump in thick ascending loop of Henle;
highly protein-bound, NOT filtered! needs to be secreted into tubule for its action
furosemide
what drug should be used with furosemide due to side effect of activating RAAS further
ACEi
name 6 side effects of furosemide
- hypokalaemia, hyponatraemia
- activates RAAS further
- hypocalcaemia, hypomagnesaemia
- metabolic alkalosis
- excessive dehydration
- can aggravate azotaemia
name the diuretic
weak diuretic, end DCT;
competitive antagonist of aldosterone R;
slow onset of action (days);
improved absorption with food;
effects on myocardial fibrosis
spironolactone
name the diuretic
weak diuretic, end DCT;
inhibits Na+ channel in DCT;
combined with hydrochlorthiazide
amiloride
name the diuretic
inhibit the Na+/Cl- cotransporter in DCT;
better diuretic than K+ sparing;
oral formulation (8-12h duration);
slow onset of action (12h);
side effects: hypokalaemia, hyponatraemia, hypochloraemia
hydrochlorothiazide
name the vasodilator
blocks conversion to Angiotensin II
(RAAS activated in CHF)
ACEi
name 2 ACEi drugs that can be used to decrease afterload in CHF
- Benazepril
- Enalapril
name the vasodilator
inodilator - positive inotrope (calcium sensitiser);
phosphodiesterase III inhibitor (peripheral vasodilation);
phosphodiesterase V inhibitor (pulmonary hypertension)
pimobendan
name the vasodilator
acute management of LCHF in dogs;
glyceryl trinitrate (Percutol cream) & Sodium Nitroprusside;
mediates vasodilation through cGMP
nitric oxide donors
name the drug
used for inotropic support in patients with acute HF, septic shock;
used to support myocardial function during GA;
synthetic beta1 adrenergic agonist;
can induce arrhythmias caused by intracellular calcium overload
Dobutamine
name the drug
weak positive inotropy (use in DCM in dogs);
negative chronotropy (antiarrhythmic in dogs);
from Digitalis purpurea (foxglove);
blocks Na+/K+ ATPase leading to incr. intracellular Na+
Digoxin
name the 3 most common congenital cardiac diseases in dogs
- subaortic stenosis
- pulmonic stenosis
- patent ductus arteriosus
name the 2 more common congenital cadiac diseases in cats
- ventricular septal defects
- atrioventricular valve dysplasia
name 5 dog breeds that are predisposed to subaortic stenosis
- boxers
- newfoundland
- GSD
- golden retrievers
- rottweiler
name 3 clinical findings on physical exam that indicate subaortic stenosis
- sytolic murmur
- PMI left heart base
- poor pulse quality
what should be used to diagnose subaortic stenosis
echocardiography
what breed is most commonly predisposed to pulmonic stenosis
bull dogs
(but also several breeds)
name 1 clinical finding on physical exam that may indicate pulmonic stenosis
- systolic murmur (left heart base)
what should be used to diagnose pulmonic stenosis in a dog
echocardiography
what 2 signs of pulmonic stenosis may be seen on radiographs
- right-sided enlargement
- post-stenotic dilatation
what direction of shunting is the most common in patent ductus arteriosus (PDA)
left to right shunting
name 3 clinical findings on physical examination that may indicate a PDA
- continuous “machinery” murmur
- “water-hammer”/bounding pulse
- PMI left base
what 2 signs of PDA are usually seen on radiographs
- left-sided enlargement
- pulmonary overcirculation
what is the treatment for a PDA
closure of the PDA
what dog breed is most predisposed to mitral valve dysplasia
english bull terriers
what sign of mitral valve dysplasia may be seen on radiographs
left-sided enlargement
name 2 signs of mitral valve dysplasia that may be seen on electrocardiography
- left atrial enlargement
- left ventricular enlargement
what does mitral valve dysplasia lead to
left-sided congestive heart failure
what does tricuspid valve dysplasia lead to
right-sided congestive heart failure
what breed is the mose predisposed to tricuspid valve dysplasia
labradors
what sign of tricuspid valve dysplasia may be seen on radiographs
right-sided enlargement
name 2 signs of tricuspid valve dysplasia that may be shown on electrocardiography
- right-sided enlargement
- splintered QRS
what direction of shunting is most common in a ventricular septal defect
left to right shunting
what breed is the most predisposed to ventricular septal defect
english springer spaniel
(and cats!)
name 2 signs of ventricular septal defect that may be seen on radiographs
- left (+/- right) enlargement
- pulmonary overcirculation
is the systolic murmur louder with a smaller or bigger ventricular septal defect
louder with smaller hole
what 3 things does stenisus cause
- pressure overload
- concentric hypertrophy
- forward and backward failure
what 3 things do leaks and holes in the heart cause?
- volume overload
- eccentric hypertrophy
- backward failure
what is the most common cardiac disease in dogs?
myxomatous mitral valve disease (MMVD)
name the cardiac disease
the basic, thin, mitral valve structure is disrupted and distorted by expansion of the matrix of the spongiosa;
the valve leaks leading to a systolic murmur
myxomatous mitral valve disease (MMVD)
how does age affect myxomatous mitral valve disease (MMVD)
severity and leak increases with age
as preload increases, which part of the heart enlarges?
left atrium
which part of the heart enlarges with eccentric hypertrophy?
left ventricle
a leakly mitral valve causes volume overload which eventually leads to what kind of heart failure?
left-sided congestive heart failure
backward or forward heart failure signs?
- cough
- dyspnoea
- abdominal distension
backward failure signs
backward or forward heart failure signs?
- exercise intolerance
- lethargy
- syncope
forward failure signs
which comes first in myxomatous mitral valve disease (MMVD), backward or forward failure signs?
backward failure signs
name 2 biomarkers from blood samples that can aid management and diagnosis of congestive heart failure
- Troponin-I
- NT-proBNP
name the biomarker
released according to atrial stretch and ventricular wall stress
pro-BNP
what diagnostic is required in order to diagnose left-sided congestive heart failure?
chest radiograph
acute presentations of congestive heart failure in a dog with MMVD is often due to the rupture of what structure?
chordae tendinae rupture
(less likely: left atrial rupture)
name the 4 drugs/therapies used to treat acute congestive heart failure
- Furosemide IV
- Oxygen
- Nitroglycerine ointment
- Pimobendan
(reach for phone, then have a pee)
if you have to choose, what are the 2 most important drugs for treating congestive heart failure
furosemide + pimobendan
name two predictors of congestive heart failure;
increase in the 4 months before stage C of failure
- incr. HR
- incr. RR
(BW decreases by 3%)
the valves on which side of the heart are affected by bacterial endocarditis?
left side
name the 2 commonest sites of bacterial endocarditis in dogs & cats
- mitral valve
- aortic valve
(left side of heart)
name 4 non-specific signs of malaise that dogs with bacterial endocarditis typically present with
- pyrexia
- joint stiffness
- new murmur
- diastolic murmure over left heart base
what is the treatment for bacterial endocarditis?
supportive care and antibiotics
what 3 signs should be seen in a chest radiograph to diagnose CHF (congestive heart failure) in dogs with MMVD (myxomatous mitral valve disease)?
- left atrial/auricular enlargement
- pulmonary venous congestion
- peri-hilar pulmonary oedema
what chemotherapy drug can cause secondary DCM (dilated cardiomyopathy)
Doxorubicin
name 3 nutritional causes of secondary DCM (dilated cardiomyopathy)
- taurine deficiency
- carnitine deficiency
- “BEG” diets
what is the main histopathological feature of DCM (dilated cardiomyopathy)
wavy myocardial fibres
what value should always be measured to aid in diagnosis, prognosis and management of DCM (dilated cardiomyopathy)
T4/TSH
what makes the definitive diagnosis of DCM (dilated cardiomyopathy)
echocardiography
is echocardiography necessary to diagnose myxomatous mitral valve disease (MMVD)?
no, can diagnose with just stethoscope
what drug can be used to incr. contractility and prolong pre-clinical period of DCM (dilated cardiomyopathy)
(does not cure it)
Pimobendan
(PROTECT study)