Toxicity Side effects Flashcards

1
Q

When to monitor for Lithium

A

weekly until stable
—> every 3 months (year 1)
——-> every 6 months

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2
Q

When do you record Lithium serum concentration

A

12 hours after dose

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3
Q

Signs of Lithium Toxicity
SICK and TREMOR

A
  • nausea
  • tremor
  • increased weeing/thirst
  • headache
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4
Q

What organ is not affected by lithium

A

Liver

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5
Q

What is the therapeutic range for Digoxin

A

0.7 to 2

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6
Q

When should Digoxin samples be taken

A

6 hours after dose

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7
Q

What are the signs of Digoxin toxicity apart from Yellow vision

A
  • sick
  • confused
  • palpitations
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8
Q

What is a rare syndrome you should not give digoxin with

A

Wolff-Parkinson-White Syndrome

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9
Q

What can be a sign of bone marrow toxicity when taking methotrexate

A

Mucositis (inflammation of mouth of gut)

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10
Q

What requires discontinuation of methotrexate

A
  • pulmonary toxicity
  • bone marrow supression/neutropenia
  • Diarrhoea
  • Oral mucositis
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11
Q

What should be monitored in methotrexate

A
  • blood
  • renal
  • liver
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12
Q

When should Methotrexate monitoring take place

A
  • every 1 to 2 weeks until stable
    —-> every 2 to 3 months
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13
Q

What should the monitoring frequency be for Methotrexate when taking Leflunomide

A

monthly for 12 months

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14
Q

What should be monitored with Warfarin

A
  • FBC
  • LFT
  • renal
  • BP
  • thyroid
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15
Q

What are signs of toxicity for Theophylline
SICK and FAST

A
  • Nausea
  • tremor
  • palpitations
  • hyperglycaemia
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16
Q

What to not have with Phenytoin

A
  • Enteral feeding (stop it 2 hours before and after dose)
17
Q

What supplements might be needed for when taking Phenytoin

A

Vitamin D

18
Q

When to stop Phenytoin

A

if rash appears

19
Q

When to discontinue ciclosporin

A
  • uncontrolled hypertension
  • peripheral neuropathy
  • hair loss
  • rash
20
Q

What is the interaction of statins and cyclosporin

A

myopathy

21
Q

When to measure serum concentration of gentamycin

A

after 3rd or 4th dose

22
Q

What are the serum ranges for Vancomycin

A

10 to 20

23
Q

What are the signs of toxicity of vancomycin

A
  • sore throat
  • brusing
  • mouth ulcers
24
Q

How long after treatment does amiodarone still incur side effects

A

several weeks to months

25
Q

What can amiodarone do to neonates

A

goitre (swelling of thyroid glands in neck)

26
Q

Can you breast feed with amiodarone

A

NO

27
Q

What is a long term affect of Heparins

A

Osteoporosis

28
Q

What cyclophosphamide cause and how to treat it

A

haemorrhagic cystitis

(treated with mensa)

29
Q

What is cyclophophammide induced hemorrhagic cystitis

A

inflammation and bleeding from bladder lining

30
Q

How long post cyclophosphamide treatment should contraception go on for, for each gender

A

Females (12 months)

Males (6 months)

31
Q

Hypoglycaemia effects

A
  • palpitations
  • rapid heart beat
  • sweating
32
Q

What are the interactions of Sulfonylureas

A
  • BB
  • NSAIDs
  • Alcohol