Phenytoin Flashcards
1
Q
What protein is Phenytoin mostly bound to
A
Albumin
2
Q
When is albumin low
A
liver impairment
3
Q
What impact dose liver impairment have on phenytoin levels
A
increase unbound phenytoin, increasing toxicity
4
Q
What is recommended in phenytoin patients who are immobile, limited exposure to sun or limited calcium intake
A
Vitamin D supplement
5
Q
Patients who carry HLA allele are at risk of what when taking Phenytoin
A
Stevens Johnsons Syndrome
6
Q
Which patient group have an increased chance of carrying HLA allele
A
Chinese and Thai
7
Q
What can phenytoin cause
A
- hyperglycaemia
- gingival hyperplasia
8
Q
What should you do if a rash occurs while taking phenytoin
A
stop taking
9
Q
What substance increase sedative effect of Phenytoin
A
Alcohol
10
Q
Symptoms of Phenytoin toxicity
A
- confusion
- ataxia (lack of muscle coordination)
- nystagmus (involuntary movements)
