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Important to Study > Interactions Part 2 > Flashcards

Interactions Part 2 Flashcards

1
Q

What is the interaction between methotrexate and fluconazole?

A

Increases risk of liver toxicity

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2
Q

What is the interaction between methotrexate and isotretinoin?

A

Increased risk of liver toxicity

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3
Q

What is the interaction between methotrexate and penicillins?

A

Reduced clearance of methotrexate (if short course up to 10 days - consider using and monitor for signs of methotrexate toxicity)

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4
Q

What is the interaction between methotrexate and PPIs?

A

Reduced methotrexate clearance - consider H2-receptor antagonists as alternative

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5
Q

What is the interaction between methotrexate and statins?

A

Increased risk of liver toxicity

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6
Q

What is the interaction between methotrexate and tamoxifen?

A

Increased risk of liver toxicity

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7
Q

What is the interaction between methotrexate and terbinafine?

A

Increased risk of liver toxicity

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8
Q

What juice decreases ciclosporin concentration?

A

Purple grape juice

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9
Q

What is the interaction between an SSRI and NSAIDs

A

GI bleed

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10
Q

What is the interaction between Ibuprofen and ramipril

A

Nephrotoxicity

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11
Q

What is the interaction between simvastatin and amlodipine

A

myopathy

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12
Q

What is the interaction between ramipril and spironolactone

A

Hyperkalaemia

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13
Q

What is the interaction between bisoprolol and donepezil?

A

Bradycardia

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14
Q

What would cause a pharmacodyamic interaction with donepezil?

A

Oxybutynin - anticholinergic drugs counteract what this does because donepezil prevents the breakdown of acetylcholinterase in the brain whereas anticholingeric drugs does the opposite

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15
Q

What is the interaction between sodium valproate and doxycycline?

A

Risk of hepatotoxicity

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16
Q

Do SSRIs impact epilepsy?

A

SSRIs lower seizure threshold

17
Q

What is the interaction between sildenafil and nitrates?

A

CONTRAINDICATED - risk of hypotension

18
Q

What is the interaction between alpha blockers and sildenafil?

A

Risk of hypotension

19
Q

What is the interaction between ACEi and insulin or other oral antidiabetics?

A

Hypoglycaemia

20
Q

What is the interaction between lithium and candesartan?

A

Candesartan increases concentration of lithium

21
Q

What do MAOIs interact with?

A

Tyramine: the cheese effect - hypertensive crisis

Sympathomimetics: pseudoephedrine, epherdrine - hypertensive crisis

Sumatriptan: increases exposure to sumatriptan - avoid for 14 days after stopping MAOI

Other antidepressants: washout period

Lithium: increased risk of serotonin syndrome

Important to Study (60 decks)

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