MHRA Warnings Part 5

Question 1

What can occur due to abrupt withdrawal of Baclofen

Answer 1

Hyperactive state
(convulsions, hyperthermia, spasticity)

Question 2

What time of day should you not take ispaghula preparations

Answer 2

before bed

Question 3

How long after stopping Disulfiram therapy should patients not drink alcohol

Answer 3

14 days

Question 4

How can heat and cold affect insulin absorption

Answer 4

Heat:
increase absorption

Cold:
reduce absorption

Question 5

What should you avoid when taking Isotretinoin and 6 months after stopping

Answer 5

• Wax epilation
• laser skin treatments

Question 6

What should be monitored when starting aminosalicylates and when

Answer 6

Renal function

• before
• at 3 months
• annually

Question 7

When should you discontinue rifampicin and isoniazide

Answer 7

• persistant N + V
• jaundice
• dark urine

(liver toxicity)

Question 8

What should be stopped before surgery due to renal perfusion/ tissue damage and hyperkalaemia

Answer 8

Potassium sparing diuretics

Question 9

What should be stopped 24 hours before surgery to avoid severe hypotension after anaesthesia

Answer 9

ACEi / ARBs

Question 10

Should Lithium be stopped for Major and Minor Surgeries

Answer 10

Minor:
NO

Major:
YES (24 hours before)