toxicities and side effects

Question 1

antidote for acetaminophen?

Answer 1

NAC

replenishes glutathione

Question 2

antidote for AChE inhibitors, organophosphates?

Answer 2

atropine > pralidoxime

Question 3

antidote for amphetamines?

Answer 3

NH4Cl

acidify urine

Question 4

antidote for antimuscarinic or anticholinergic agents?

Answer 4

physostigmine

control hyperthermia

Question 5

antidote for BZOs?

Answer 5

flumazenil

Question 6

antidote for CO poisoning?

Answer 6

100% O2

hyperbaric O2

Question 7

antidote for BBs?

Answer 7

glucagon

Question 8

antidote for copper, arsenic, gold?

Answer 8

penicillamine

Question 9

antidote for cyanide?

Answer 9

nitrite + thiosulfate, hydoxycobalamin

Question 10

antidote for dig?

Answer 10

anti-dig Fab fragments

Question 11

antidote for heparin?

Answer 11

protamine

Question 12

antidote for iron?

Answer 12

deferoxamine, deferasirox

Question 13

antidote for lead?

Answer 13

EDTA, dimercaprol, succimer, penicillamine

Question 14

antidote for mercury, arsenic, gold?

Answer 14

dimercaprol (BAL), succimer

Question 15

antidote for methanol, ethylene glycol?

Answer 15

fomepizole > ethanol, dialysis

Question 16

antidote for methemoglobin?

Answer 16

methylene blue, vitamin c

Question 17

antidote for opioids?

Answer 17

naloxone, naltrexone

Question 18

antidote for salicylates?

Answer 18

NaHCO3 - alkalinize urine

dialysis

Question 19

antidote for TCAs?

Answer 19

NaHCO3 - alkalinize plasma

Question 20

antidote for tPA, streptokinase, urokinase?

Answer 20

aminocaproic acid

Question 21

antidote for warfarin?

Answer 21

vit K (delayed)
FFP (immediate)

Question 22

what drugs cause coronary vasospasm?

Answer 22

cocaine
sumatriptan
ergot alkaloids

Question 23

what drugs cause cutaneous flushing?

Answer 23

VANC
vanc
adenosine
niacin
CCBs

Question 24

what drugs cause dilated cardiomyopathy?

Answer 24

anthracyclines = doxorubicin, daunorubicin

** prevent with dexrazoxane

Question 25

what drugs cause torsades?

Answer 25

Ia and III antiarrhythmics macrolide ABx antipsychotics TCAs

Question 26

what drugs cause hyperglycemia?

Answer 26

Taking Pills Necessitates Having (blood) Checked ``` tacrolimus protease inhibitors niacin HCTZ corticosteroids ```

Question 27

what drugs cause hypothyroidism?

Answer 27

lithium amio sulfonamides

Question 28

what drugs cause acute cholestatic hepatitis?

Answer 28

erythromycin

Question 29

what drugs cause diarrhea?

Answer 29

``` metformin erythromycin colchicine orlistate acarbose ```

Question 30

what drugs case hepatic necrosis?

Answer 30

halothane amanita phalloides (blocks RNA pol II) VPA acetaminophen

Question 31

what drugs cause hepatitis?

Answer 31

``` rifampin INH pyrazinamide statins fibrates ```

Question 32

what drugs cause pancreatitis?

Answer 32

Drugs Causing A Violent Abdominal Distress ``` didanosine corticosteroids alcohol VPA azathioprine diuretics ```

Question 33

what drugs cause pseudomembranous colitis?

Answer 33

clinda amp cephalosporins

Question 34

what drugs cause agranulocytosis?

Answer 34

``` ganciclovir clozapine carbamazepine colchicine methimazole PTU ```

Question 35

what drugs cause aplastic anemia?

Answer 35

``` carbamazepine methimazole NSAIDs benzene chloramphenicol PTU ```

Question 36

what drugs cause direct coombs+ hemolytic anemia?

Answer 36

methyldopa | PCN

Question 37

what drugs cause grey baby syndrome?

Answer 37

chloramphenicol

Question 38

what drugs cause G6PD hemolysis?

Answer 38

``` INH sulfonamides dapsone primaquine aspirin ibuprofen nitrofurantoin ```

Question 39

what drugs cause megaloblastic anemia?

Answer 39

phenytoin methotrexate sulfa drugs

Question 40

what drugs cause fat redistribution?

Answer 40

Fat PiG! protease inhibitors glucocorticoids

Question 41

what drugs cause gingival hyperplasia?

Answer 41

phenytoin CCBs cyclosporine

Question 42

what drugs cause hyperuricemia?

Answer 42

``` pyrazinamide thiazides furosemide niacin cyclosporine ```

Question 43

what drugs cause myopathy?

Answer 43

``` fibrates niacin statins colchicine hydroxychloroquine IFN-a penicillamine glucocorticoids ```

Question 44

what drugs cause osteoporosis?

Answer 44

glucocorticoids | heparin

Question 45

what drugs cause photosensitivity?

Answer 45

SAT For Photo sulfonamides amiodarone tetracyclines 5-FU

Question 46

what drugs cause SJS?

Answer 46

anti-epileptics (esp lamictal) allopurinol sulfa drugs PCN

Question 47

what drugs cause drug-induced lupus?

Answer 47

``` sulfa hydralazine INH procainamide phenytoin etanercept ```

Question 48

what drugs cause cinchonism?

Answer 48

(tinnitus, HA, confusion) quinidine quinine

Question 49

what drugs cause parkinson-like syndrome?

Answer 49

antipsychotics reserpine metoclopramide

Question 50

what drugs cause seizures?

Answer 50

INH (via B6 deficiency) bupropion imipenem/cilastin enflurane

Question 51

what drugs cause tardive dyskinesia?

Answer 51

antipsychotics | metoclopramide

Question 52

what drugs cause DI?

Answer 52

lithium | demeclocycline

Question 53

what drugs cause Fanconi syndrome?

Answer 53

expired tetracycline

Question 54

what drugs cause hemorrhagic cystitis?

Answer 54

cyclophosphamide ifosfamide ** prevent by coadmin with MESNA

Question 55

what drugs cause interstitial nephritis?

Answer 55

methicillin NSAIDs lasix

Question 56

what drugs cause SIADH?

Answer 56

carbamazepine cyclophosphamide SSRIs

Question 57

what drugs cause pulmonary fibrosis?

Answer 57

bleomycin amiodaraone busulfan methotrexate

Question 58

what drugs cause disulfiram-like rxn?

Answer 58

``` mteronidazole some cephalosporins griseofulvin procarbazines 1st gen sulfonylureas ```

Question 59

what drugs cause nephrotoxicity or ototoxicity?

Answer 59

AGs vanc loop diurects cisplatin (try amifostine if cisplatin tox)

Question 60

CYP450 inducers?

Answer 60

``` chronic alcohol St John's wort phenytoin phenobarbital nevirapine rifampin griseofulvin carbamazepine ```

Question 61

CYP450 substrates?

Answer 61

anti-epileptics theophylline warfarin OCPs

Question 62

CYP450 inhibitors?

Answer 62

``` acute alcohol ritonavir amiodarone cimetidine ketoconazole sulfonamides INH grapefruit juice quinidine macrolides (NOT azithro) ```

Question 63

what are the sulfa drugs?

Answer 63

``` probenecid lasix acetazolamide celecoxib thiazides sulfonamides sulfasalazine sulfonylureas ```