repro Flashcards
leuprolide?
GnRH analog
agonist when pulsatile (infertility)
antagonist when constant (prostate ca, fibroids, precocious puberty)
tox: antiandrogen, N/V
contraindications to estrogen use?
ER+ brca
history of DVTs
clomiphene?
hypothalamic estrogen rcptr antagonist –> prevents feedback inhib –> increased LH and FSH release –> ovulation
used for infertility 2/2 anov (e.g. PCOS)
tox: hot flashes, ovarian enlargement, multiple pregs, visual disturbances
anastrozole/exemestane?
aromatase inhibitors
used in postMP women with ER+ brca
mifepristone?
competitive inhib of progestins at progesterone rcptr
used to terminate preg with misoprostol
tox: heavy bleeding, GI effects, abd pain
OCPs contraindicated in?
smokers > 35
hx of VTE/stroke
hx of E-dependent tumor
terbutaline, ritodrine?
B2 agonists
relax uterus
used to decrease ctx frequency in labor
danazol?
synthetic androgen - partial agonist at androgen rcptrs
uses: endometriosis, hereditary angioedema
tox: weight gain, edema, acne, hirsutism, masculinization, decreased HDL, hepatotoxicity
uses of T/methylT?
hypogonadism, promote development of 2ary sex characteristics
stimulate anabolism –> promote recovery after burn/injury
T/methylT toxicity?
masculinization in females
gonadal atrophy in males
premature closure of epiphyseal plates
increased LDL and decreased HDL
finasteride?
5a reductase inhib
BPH, male pattern baldness
flutamide?
nonsteroidal
competitive inhib at androgen receptors
used for prostate ca
ketoconazole?
inhibits steroid synth - inhibits 17,20 desmolase –> reduce androgenic sx in PCOS
tox: gynecomastia, amenorrhea
spironolactone?
inhibits steroid binding, 17a hydroxylase, 17,20 desmolase
reduces androgenic sx in PCOS
tox: gynecomastia, amenorrhea
