psych Flashcards
high potency typical antipsychotics?
trifluoperazine
fluphenazine
haloperidol
low potency typical antipsychotics?
chlorpromazine
thioridazine
MOA of typical antipsychotics?
increase cAMP –> block D2 rcptrs
typical antipsychotic toxicity?
highly lipid soluble, stored in body fat QT prolongation extrapyramidal endocrine muscarinic blockade alpha 1 blockade histamine blockade
rigidity, myoglobinuria, autonomic instability, hyperpyrexia?
NMS
give dantrolene, D2 agonists (bromocriptine)
MOA of atypical antipsychotics?
affect 5HT2, dopa, alpha, H1
not well understood
which atypical antipsychotics cause weight gain?
olanzapine
clozapine
which atypical antipsychotic needs weekly CBCs?
clozapine!
risk of agranulocytosis (also sz)
lithium SEs?
tremor
DI
hypothyroidism
Ebstein anomaly
**thiazide use implicated in Li toxicity
buspirone?
5HT1a stimulation
used in GAD; no sedation/addiction/tolerance
no interaction with alcohol
hyperthermia, confusion, myoclonus, cardiovascular instability, flushing, diarrhea, sz?
serotonin syndrome
** tx: cyproheptadine (5HT2 antagonist)
TCA toxicity?
sedation, alpha1 blockade, anticholinergic, long QT
convulsions, coma, cardiotoxicity
** tx: NaHCO3
mirtazapine?
antidepressant
alpha2 antagonist and 5HT2/5HT3 antagonist
** toxicity: sedation, increased appetite, weight gain
trazodone?
blocks 5HT2 and alpha1
insomnia; high doses needed for antidepressant
** toxicity: boners! also sedation, nausea, postural hypoT.
bupropion?
increases NE and dopa
** tox: tachy, insomnia, HA, seiiiiizures! don’t give to anorexic/bulimic pts
