Topical Skin Therapeutics Flashcards

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1
Q

Name a common mild topical steroid

A

Hydrocortisone 1%

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2
Q

Capsaicin is useful in the treatment of what?

A

Pruritis

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3
Q

Why is capsaicin useful in the treatment of pruritis?

A

Depletes substance P at nerve endings and reduces the neurotransmission which would normally aid pruritis

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4
Q

What is commonly used to treat ringworm (dermatophytes)?

A

Clotrimazole

Terbinafine

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5
Q

In which condition are steroids generally avoided, or used with extreme caution?

A

Roseacea

(can cause steroid-induced rosacea)

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6
Q

What is the main advnatge for topical treatment?

A

Reduces systemic effects

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7
Q

Topical corticosteroids have which 3 main effects?

A
  1. Anti-inflammatory
  2. Antiproliferative
  3. Vasoconstrictive
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8
Q

Which topical treatment is used in every case of psoriasis?

A

Emollient

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9
Q

Besides emollients, which other treatments can be used for psoriasis?

A

Coal tar

Vitamin D analogue

Keratolytic

Topical steroids

Dithranol

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10
Q

What is nystatin?

A

Topical antifungal

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11
Q

How can candida be treated?

A

Nystatin

Clotrimazole

Oral fluconazole

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12
Q

What is tachyphylaxis?

A

Decrease in response to anti-inflammatory effects

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13
Q

Name a potent steroid

A

Mometasone

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14
Q

When thin skin becomes a problem with steroid use, what is an alternative class of drugs?

A

Calicneurin inhibitors

(tacrolimus or pimecrolimus)

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15
Q

How do calcineurin inhibitors work?

A

Suppress lymphocyte activation

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16
Q

Which dermatological condition are calcineurin inhibitors typically used for?

A

Eczema

17
Q

Which side effect do steroids have which calcineurin inhibitors avoid?

A

Thin skin

18
Q

What are the side effects of calcineurin inhibitors?

A

Burning sensation on application is commonly reported

Increase risk of cutaneous infection

Skin cancer (with chronic use)

19
Q

Which effective treatment for psoriasis is irritant and will stain normal skin?

A

Dithranol

20
Q

Which steps can ensure emollients are applied to ensure the best results?

A

Apply after bathing

Apply at least once per day

Apply in the direction of hair growth

Use a spoon or spatula to remove the emollient when applying