Cutaneous Drug Eruptions Flashcards
Drug induced bullous pemphigoid is associated with which drug?
ACE inhibitors
Furosemide
Penicillin
What is the most common morphology of drug eruption in the skin?
Exanthematous/Morbilliform/Macropapular - 75-95%
(urticarial is second most common)
Which features indicate that an exanthemous drug eruption is severe?
Involvement of mucous membranes and face
Facial oedema and erythema
Widespread confluent erythema
Fever
Blisters
Purpura
Necrosis
What comprises an urticarial rash?
Erythema and wheals
Which type of hypersensitivity is associated with pemphigus and pemphigoid?
Type II
Which hypersensitivity type is associated with eczema?
It is not immunologically mediated
Linear IgA disease can be brought on by which drug?
Vancomycin
Where is the deposition of IgA in linear IgA disease?
Along the basement membrane
How are blisters arranged in linear IgA disease?
A string of peals
What is linear IgA disease?
IgA is deposited at the basement membrane
Paients present with pemphigoid or dermatitis herpitiformis like presentations, but IgA is present instead of IgG at the basement membrane
It is associated with Vancomycin
Which types of drugs are associated with pustular/bullous drug eruptions (acne)?
Glucocorticoids
Androgens
Lithium
Isoniazid
Phenytoin
Which type of drug reaction is associated with immediate prickling with delayed erythema and pigmentation?
Photosensitivity
Which drgs are commonly associated with photosensitivity
Amiodarone
Chlorpromazine
Thiazides
NSAIDs
Psoralens
Antibiotics (fluroquinolones, tetracyclines)
Exanthematous drug eruptions are caused due to what?
Type IV
(usually mild and self limiting widespread rash which avoids the mucous membranes)
Which type of symptoms are associated with Stevens-Johnsons syndrome and Toxic Epidermal Necolysis
Cutaneous and systemic
Which drugs have fixed drug eruptions?
Tetracycline
Doxycyline
Paracetamol
NSAIDs
Carbamazepine
How can fixed drug eruptions be described?
Well demarkated plaques (round/ovoid) which resolve with persistant pigmentation after drug withdrawal
Where do fixed drug eruptions typically occur?
Hands
Genitalia
Lips
Oral mucosa (occasional)
Fixed drug eruptions will occur on the ________ ________ if the drug is reintroduced
Fixed drug eruptions will occur on the same site if the drug is reintroduced
Which sex is more susceptible to drug eruptions?
Females
What is the normal time frame for a type IV hypersensitivity reaction?
4-21 days
Which type of hypersensivity reaction is psoriasis associated with?
It is not immunologically mediated
