Pathology of Rashes Flashcards
Which type of dermatitis has a strong connection with coeliac disease?
Dermatitis herpetiformis
Pemphigus vulgaris is ____ mediated
Pemphigus vulgaris is IgG mediated
Pemphigus vulgaris is an autoimmune condition
True or false?
True
After taking a skin sample in a patient with rosacea, what is often seen under microscopy?
Demodex folliculorum mites
(in the pilosebaceous units)
In which situation may bellous pemphigoid mimic pemphigus vulgaris?
Older lesions of bullous pemphigoid heal and re-epithelialise making the lesions look as if they have involved the epidermis
Which type of pemphigus is the most common?
Pemphigus vulgaris
How does pemphigus vulgaris often begin?
Mouth blisters
How can pemphigus foliaceus be differentiated from pemphigus vulgaris?
Mouth blistering does not occur
Which type of pemphigus is described by:
“Thick painful lesions develop in the groin and axilla region”?
Pemphigus vegetans
Which type of pemphigus is described by:
“Blistering usually begins on the face and scalp which progresses to the chest and back. Blisters are not sore, but itchy. The skin is host to numerous moist scales and there are no mouth ulcers”
Pemphigus foliaceus
What is the least harmful variant of pemphigus?
IgA pemphigus
IgA pemphigus is most visually similar to which other form of pemphigus?
Pemphigus foliaceus
Which type of pemphigus is very rare and associated with people suffering from cancer?
Paraneoplastic pemphigus
What are potential signs and symptoms for paraneoplastic pemphigus?
- Mouth and lip sores
- Lesions on the eye and eyelid lining
- Skin blistering
- Serious lung issues
It is a very challenging condition to diagnose
Which features are associated with Rosacea?
- Recurrent facial flushing
- Telangiectasia
- Pustules
- Thickening of the skin
- Rhinophyma
Rosacea is more common in which gender?
Females
Where are blisters usually present within the skin in a patient with bullous pemphigoid?
Basement membrane of the epidermis
Which factors can aggravate rosacea?
- Hot/spicy food
- Exercise
- Emotion
- Alcohol
- Sunlight
Which term refers to the persistance of nuclei within the keratin layer?
Parakeratosis
What is the process behind the development of pemphigus vulgaris?
- IgG antibodies form to desmoglein 3
- Desmosomal attachments are destroyed as immune complexes form and complement/proteases are released
- Blisters form
- Acantholysis occurs - the loss of intercellular connections