Pruritis Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Which substances can induce mast cell degranulation?

A
  1. Substance P
  2. IgE
  3. Allergen
  4. C5a
  5. Opiates
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the four causes of itch?

A
  1. Pruritoceptive causes
  2. Neurogenic causes
  3. Neuropathic causes
  4. Psychogenic causes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which class of drug is ondansetron?

A

Opiate antagonist

(for serotonin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are three classes of itch mediators?

A
  1. Chemical mediators in the skin - histamine, acetylcholine, substance P etc
  2. Nerve transmission - Unmyelinated C fibres
  3. Central nervous system mediators - Opiates
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

In nerve fibres are exposed (unmyelinated), yet not damaged, which cause of itch is involved?

A

Pruritoceptive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which cause of itch is associated with damage to central or peripheral nerves?

A

Neuropathic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How can neurogenic itch be described?

A

Itch which originates in the CNS yet there is no evident damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Insect bite reaction involves which type of itch?

A

Pruritoceptive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is doxepin?

A

Antidepressant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which type of antihistamines must be used to treat itch?

A

Sedative antihistamines (usually first generation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which anti-histamine is commonly used to treat itch?

A

Chlorophenamine maleate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Pruritoceptive itch can be defined in which way?

A

Something usually associated with inflammation or dryness in the skin which triggers itch

(e.g. insect bite)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name 3 pre-formed mediators from mast cells

A
  1. Proteases
  2. Histamine
  3. Heparin
  4. Cytokines
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name mediators which are synthesised post-degranulation in mast cells

A
  1. Prostaglandin D2
  2. Leukotrienes C4, D4 and E4
  3. Platelet activating factor
  4. Cytokines
How well did you know this?
1
Not at all
2
3
4
5
Perfectly