Topical Abx w/ various MOA

Question 1

What is the spectrum and MOA for Bacitracin?

Answer 1

Spectrum: MSSA, Streptococcus pyogenes. MOA: Non-beta-lactam, interferes with cell wall synthesis.

Question 2

What is Bacitracin used for?

Answer 2

Topical administration for skin conditions like impetigo and eye infections.

Question 3

What are the common uses for Polymyxin B?

Answer 3

Topical administration for skin and eye conditions; often part of triple antibiotic ointments.

Question 4

Which bacteria does Polymyxin B target?

Answer 4

MSSA, Streptococcus pyogenes, Gram-negative bacilli including E.coli, Enterobacter, Klebsiella, Pseudomonas, Shigella

Question 5

What is Mupirocin’s spectrum of activity and MOA?

Answer 5

Spectrum: Gram-positive cocci. MOA: Protein synthesis inhibitor.

Question 6

How is Mupirocin administered and what does it treat?

Answer 6

Topically for skin conditions such as impetigo.

Question 7

What kind of adverse reactions can all these topical drug classes cause?

Answer 7

Localized topical reactions.