Antifungal & Antivirals Flashcards
What is the mechanism of action of Tamiflu (Oseltamivir)?
Neuraminidase inhibitor (an enzyme needed to release viral particles from infected cells)
What are the age recommendations and dosing for Tamiflu (Oseltamivir)?
2-13 yo based on weight, 13 & older: 75mg BID 5d, Prophylaxis: 75mg daily x 10d; See age column
What are the common side effects of Tamiflu (Oseltamivir)?
HA, N/V/D
What are the contraindications or cautions associated with Tamiflu (Oseltamivir)?
If patient has renal impairment, must adjust dose
What is the mechanism of action of Relenza (Zanamivir)?
Neuraminidase inhibitor
What are the age recommendations and dosing for Relenza (Zanamivir)?
7 yo; 2 inhalations BID x5d Prophylaxis: 2 inhalations BID x10d
What are the common side effects of Relenza (Zanamivir)?
Bronchospasm cough HA N/V
What are the contraindications or cautions associated with Relenza (Zanamivir)?
Not a good option for someone with pulmonary dz or sensitive to milk protein
What is the mechanism of action of Rapivab (Peramivir)?
Neuraminidase inhibitor
What are the age recommendations and dosing for Rapivab (Peramivir)?
18 yo; 600mg IV 1 dose, No prophylaxis
What are the common side effects of Rapivab (Peramivir)?
Neutropenia Hyperglycemia Increase in ALT/AST HTN
What are the contraindications or cautions associated with Rapivab (Peramivir)?
If patient has renal impairment, adjust dose
What is the mechanism of action of Xofluza (Baloxavir marboxil)?
Cap-dependent endonuclease inhibitor (stops virus from snatching host RNA to use as a primer for viral synthesis)
What are the age recommendations and dosing for Xofluza (Baloxavir marboxil)?
12 yo; If less than 80kg: 40mg x 1dose Over 80kg: 80mg x 1dose Prophylaxis same dose
What are the common side effects of Xofluza (Baloxavir marboxil)?
N/D in geriatric pts HA
