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Bio 432 > Topic 7 - Growth Factors > Flashcards

Topic 7 - Growth Factors Flashcards

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Biology 101 flashcards
1
Q

What kind of properties do growth factors have and provide 2 examples?

A 
Mitogenic properties (stimulates mitosis)
eg) proliferation and/or differentiation
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2
Q

What are proto-oncogenes?

A

They are normal cellular genes that affect and are critical for cell growth and can become oncogenes if mutated (cause cancer)

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3
Q

NGF

A

Nerve growth factor

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4
Q

EGF

A

Epidermal growth factor

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5
Q

What happens if you dont continuously stimulate neurons?

A

They can die

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6
Q

What 2 factors should be high is a developing fetus?

A
  1. Nerve growth factor

2. Epidermal growth factor

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7
Q

What does erythropoitin stimulate?

A

Red blood cells

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8
Q

What do cytokins stimulate?

A

Immune cells

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9
Q

What do colony stimulating factors stimulate?

A

White blood cells (immune cells)

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10
Q

What do transforming growth factor beta do? (2)

A
  1. Increase FSH

2. Inhibits cell growth mostly

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11
Q

Where is IGF-1 produced?

A

Liver

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12
Q

What does IGF-1 take part in? (2)

A
  1. Protein synthesis

2. Cell proliferation

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13
Q

What does IGF-2 do?

A

Mediates GH effects

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14
Q

What is insulin important for? (2)

A
  1. Carb metabolism

2. Fetal growth

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15
Q

What does EGF do?

A

Primes infants gut to absorb nutrients

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16
Q

What happens to EGF in women who smoke?

A

EGF receptors decrease and reduce the affinity of receptors for EGF hormone causing low birth rate babies

17
Q

What happens if there are low EGF receptor number or activity?

A

May have fetal growth retardation

18
Q

What does NGF do?

A

Promotes growth and maintenance of sympathetic NS and some sensory neurons

19
Q

What do PDGF do?

A
  1. Stimulated wound healing

2. Makes cells competent to respond to IGF-1

20
Q

PDGH

A

Platelet derived growth factor

21
Q

What are 2 examples of phosphorylation cascade?

A
  1. MAPK

2. PI3K/PKB

22
Q

What disease is associated with too much growth factor?

A

Cancer

23
Q

What disease is associated with too little growth factor? (2)

A
  1. Failure to grow/thrive

2. Apoptosis

24
Q

GRB2

A

Growth factor receptor bound protein 2

25
Q

MAPK

A

Mitogen activated protein kinase

26
Q

What kind of protein is SH2 and SH3?

A

GRBP2

27
Q

What does SH3 recognize?

A

Proline-rich consensus sequence

28
Q

What does SH2 recognize?

A

Phosphorylated tyrosines on a receptor

29
Q

What does PKB pathway lead to? (2)

A
  1. Glycogen synthesis

2. Glucose transport

30
Q

What is MAPK used for?

A

Cell division

31
Q

What is rous sarcoma virus?

A

It is a single stranded RNA virus and it carries proteins that it need to the DNA

32
Q

What does rous sarcoma do?

A

It reverses transcribed RNA genome into DNA before integration into the host DNA

Bio 432 (19 decks)

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