Topic 7 Flashcards
Monohybrid inheritance
> parents diploid
100% heterozygous for F1
F2 = 3:1
Dihybrid inheritance
> F1 generation = 100% heterozygous
> F2 generation phenotypic ration = 9:3:3:1
Codominance and multiple alleles
Example - ABO blood group, A and B are codminant and o is recessive
Epistasis
> when a phenotype is controlled by more than one gene - one gene can either mask or suppress the expression of another gene
recessive epistatic allele - 9:3:4 (recessive prevents the expression of another allele)
dominant epistatic allele - 12:3:1 (one gene completely masks the alleles)
Autosomal linkage
> genes on the same autosome are linked
they will stay together during independent assortment and will be inherited together
because linked genes are inherited together they behave like a monohybrid cross
means that more offspring will have the same phenotype and genotype as their parents
Autosomal linkage and crossing over
If crossing over occurs then the alleles are separated and there will be differing genotypes and phenotypes to the parents
> closer loci is to autosome - more closely linked
Haemophilia
blood los slowly and there may be slow and persistent internal bleeding
> females have two x chromosomes and you must be homozygous recessive to suffer
Males only have one x so only need one to suffer
Normal phenotypic ratios
Monohybrid crosses - 3:1
Dihybrid crosses - 9:3:3:1
Codominant crosses - 1:2:1
Epistatic phenotypic ratios
Recessive epistatic - 9:3:4
Dominant epistatic - 12:3:1
Sex linkage phenotypic ratio
Heterozygous dominant = 3:1
Heterozygous recessive = 1:1
The hardy weinburg principle
Predicts - the frequency of alleles of a gene will stay constant over generations
Assumptions - no mutations, no selection, random mating, large population, genetically isolated, no migration
Hardy-Weinberg equation
P+Q=1
P^2 + 2pq + q^2 = 1
P = dominant
Q = recessive
Causes of variation
> most variation is a result of both
Genetic - mutation, crossing over, independent assortment, random fertilisation, inherited
Environmental causes - changes the phenotype
Speciation
> variation exists in the population due to mutation
Different selection pressures cause directional selection of differnt phenotype
differental reproductive sucess causes a change in allele frequency over many generations
Genetic drift
> affects small populations much more than large population
changes the allele frequency , is a cause of evolution
is does not depend on the environment
Directional selection
> caused by a change in environmental conditions
only those with the desired allele will survive and reproduce
mean changes
Stabilising selection
> in a stable environment
both extremes of the phenotype are less likely to survive and reproduce
the mean remains the same
Disruptive selection
> both extremes of the phenotype are more likely to survive and reproduce than the means phenotype
environment select for two separate phenotypes
contributes to sympatric speciation