Topic 2 - Gottesman et al - Disorders in offspring with two psychiatrically ill parents

Question 1

What was the aim?

Answer 1

To investigate in a large sample the probability of a child being diagnosed with a mental disorder of wither or both of their parents had this disorder.

Question 2

What was the sample?

Answer 2

Anyone in Denmark aged between 10 years and 52 years in January 2007 and with a clear link to their biological parents - 2.7 million people and their parents

Question 3

What were the four groups of people used?

Answer 3

• Two parents diagnosed with schizophrenia, bipolar, or depression
• One parent diagnosed with schizophrenia, bipolar, or depression
• Neither parent diagnosed with a disorder
• The general public

Question 4

What was the percentage of the child being diagnosed with schizophrenia when both parents have the disorder?

Answer 4

27.3%

Question 5

What was the percentage of the child being diagnosed with bipolar when both parents have the disorder?

Answer 5

24.9%

Question 6

What was the percentage of the child being diagnosed with schizophrenia when one parent have the disorder?

Answer 6

7%

Question 7

What was the percentage of the child being diagnosed with bipolar when one parent have the disorder?

Answer 7

4.4%

Question 8

What was the percentage of the chance the child being diagnosed with schizophrenia when neither parent have the disorder?

Answer 8

0.86%

Question 9

What was the percentage of the chance the child being diagnosed with bipolar when neither parent have the disorder?

Answer 9

0.48%

Question 10

What was the percentage of the general population with schizophrenia?

Answer 10

1.12%

Question 11

What was the percentage of the general population with bipolar?

Answer 11

0.63%

Question 12

What was the main conclusion?

Answer 12

Where both parents have been admitted to a psychiatric hospital with schizophrenia or bipolar disorder, their offspring are at ‘super-high risk’ of being admitted with a disorder themselves