Tissue Repair Flashcards
What is a wound
Disruption of normal anatomic structure and function
What is healing?
Complex process that results is the restoration of anatomic continuity and function
What is an acute wound?
Normally proceed through timely reparative process and results in sustained restoration of function
Chronic Wounds
Failed to produce a functional repair
What is a good dental example of a chronic wound?
Chronic Periodontitis
What are the 3 Mechanisms of Wound Repair?
Connective Tissue Deposition
Epitheliazation
Contraction
What are the 3 Normal Responses of Tissues to Injury
Resolution
Regeneration
Repair by Scar
What are the 3 Pathological Responses to Injury
Fibrosis
Dehiscence
Contracture
What are the 4 Basic Responses to an Injury
Regeneration
Normal Repair
Deficient Healing
Excessive Healing
What are the 4 Types of Wound Closure?
Primary Intention
Delayed Primary Intention
Secondary Intention
Partial Thickness Healing
What are the 3 grades of Burn Injury
Blistering
Partial Thickness
Full Thickness
What is Hemostasis?
Fibrin clotting
What are the 4 signs of mast cell degranulation
Rubor
Tumor
Calor
Dolor
What are the 4 initial actions of a responding neutrophil?
Margination
Diapedesis
Chemotaxis
Phagocytosis
What are the dental symptoms of Scurvy
Swollen Purple and Spongy Gums
Bleeding Gums
What is the optimal level of Vitamin C per day?
200 mg
What is the normal progression of wound healing
Hemostasis
Inflammation
Proliferation
Remodeling
What is the balance struck during the healing process?
Degradation vs. Synthesis
If uses for prolonged periods, what common drugs can alter wound healing process?
Anti inflammatory
What can happen with excessive scarring on skin?
Keloid
Hypertrophic
Excessive healing on Tendons?
Adhesions
Excessive healing of Nerves
Nerve blockages
Excessive healing on Joints
Ankylosis
Excessive healing on Cardiac Vessels
Athersclerosis
Excessive Healing in intestines
Crohns
Excessive Healing in tubular structures
Biliary stenosis
Esophageal stricture
Excessive healing in liver
Cirrhosis
Excessive healing in bone
Fibrotic non union
Excessive healing in gums
Gingival hyperplasia
What is the imbalance at play in gingival hyperplasia?
Collagen synthesis vs. Collagen breakdown
What are the 3 drugs usually responsible for gingival hyperplasia?
Cyclosporins (Immunosuppresion)
Phenytoin, aka Dilantin (Seizures)
Calcium Channel Blockers (Hypertension)
How do patients with Dilantin overgrowth differ from the others?
Tissues are more fibrotic with much higher levels of Connective Tissue Growth Factor (CTGF)
What are the contributing factors to a diabetic ulcer?
Neuropathy
Poor Immune Response
Infection
Are venous stasis ulcers painful or painless?
Very painful
What is periostat?
Low dose Doxycycline
What is the function of Periostat?
Inhibits synthesis and activity of Neutrophil derived MMP-8
How long can Periostat be taken?
Up to 12 months
