Tissue Repair

Question 1

What is a wound

Answer 1

Disruption of normal anatomic structure and function

Question 2

What is healing?

Answer 2

Complex process that results is the restoration of anatomic continuity and function

Question 3

What is an acute wound?

Answer 3

Normally proceed through timely reparative process and results in sustained restoration of function

Question 4

Chronic Wounds

Answer 4

Failed to produce a functional repair

Question 5

What is a good dental example of a chronic wound?

Answer 5

Chronic Periodontitis

Question 6

What are the 3 Mechanisms of Wound Repair?

Answer 6

Connective Tissue Deposition
Epitheliazation
Contraction

Question 7

What are the 3 Normal Responses of Tissues to Injury

Answer 7

Resolution
Regeneration
Repair by Scar

Question 8

What are the 3 Pathological Responses to Injury

Answer 8

Fibrosis
Dehiscence
Contracture

Question 9

What are the 4 Basic Responses to an Injury

Answer 9

Regeneration
Normal Repair
Deficient Healing
Excessive Healing

Question 10

What are the 4 Types of Wound Closure?

Answer 10

Primary Intention
Delayed Primary Intention
Secondary Intention
Partial Thickness Healing

Question 11

What are the 3 grades of Burn Injury

Answer 11

Blistering
Partial Thickness
Full Thickness

Question 12

What is Hemostasis?

Answer 12

Fibrin clotting

Question 13

What are the 4 signs of mast cell degranulation

Answer 13

Rubor
Tumor
Calor
Dolor

Question 14

What are the 4 initial actions of a responding neutrophil?

Answer 14

Margination
Diapedesis
Chemotaxis
Phagocytosis

Question 15

What are the dental symptoms of Scurvy

Answer 15

Swollen Purple and Spongy Gums

Bleeding Gums

Question 16

What is the optimal level of Vitamin C per day?

Answer 16

200 mg

Question 17

What is the normal progression of wound healing

Answer 17

Hemostasis
Inflammation
Proliferation
Remodeling

Question 18

What is the balance struck during the healing process?

Answer 18

Degradation vs. Synthesis

Question 19

If uses for prolonged periods, what common drugs can alter wound healing process?

Answer 19

Anti inflammatory

Question 20

What can happen with excessive scarring on skin?

Answer 20

Keloid

Hypertrophic

Question 21

Excessive healing on Tendons?

Answer 21

Adhesions

Question 22

Excessive healing of Nerves

Answer 22

Nerve blockages

Question 23

Excessive healing on Joints

Answer 23

Ankylosis

Question 24

Excessive healing on Cardiac Vessels

Answer 24

Athersclerosis

Question 25

Excessive Healing in intestines

Answer 25

Crohns

Question 26

Excessive Healing in tubular structures

Answer 26

Biliary stenosis

Esophageal stricture

Question 27

Excessive healing in liver

Answer 27

Cirrhosis

Question 28

Excessive healing in bone

Answer 28

Fibrotic non union

Question 29

Excessive healing in gums

Answer 29

Gingival hyperplasia

Question 30

What is the imbalance at play in gingival hyperplasia?

Answer 30

Collagen synthesis vs. Collagen breakdown

Question 31

What are the 3 drugs usually responsible for gingival hyperplasia?

Answer 31

Cyclosporins (Immunosuppresion)
Phenytoin, aka Dilantin (Seizures)
Calcium Channel Blockers (Hypertension)

Question 32

How do patients with Dilantin overgrowth differ from the others?

Answer 32

Tissues are more fibrotic with much higher levels of Connective Tissue Growth Factor (CTGF)

Question 33

What are the contributing factors to a diabetic ulcer?

Answer 33

Neuropathy
Poor Immune Response
Infection

Question 34

Are venous stasis ulcers painful or painless?

Answer 34

Very painful

Question 35

What is periostat?

Answer 35

Low dose Doxycycline

Question 36

What is the function of Periostat?

Answer 36

Inhibits synthesis and activity of Neutrophil derived MMP-8

Question 37

How long can Periostat be taken?

Answer 37

Up to 12 months