Perio Microbiology 6: Virulence Factors, P. gingivalis, A.a. Flashcards
What do virulence factors help accomplish in terms of biofilm formation?
Colonization and invasion
Adherence
Direct or Indirect host tissue damage
Evasion of host defense mechanisms
Subgingivally what are available surfaces for bacterial adherence?
Tooth/Root
Plaque mass
Tissue
Subgingivally, what species can attach to the fibrinogen and fibronectin in CT?
P. gingivalis
What is LPS?
Endotoxin
What cytokines does LPS induce?
IL-1 (fever, interferon, lymphocyte)
TNF (inflammation)
Prostaglandins (Clotting, pain, fever)
What cells release these cytokines?
Monocytes
Macrophages
PMNs
What else does the LPS induce from the host?
Cytokine production
Inflammatory response
Bone resorption
What is the virulence factor that allows for bacterial induced host tissue damage?
Collegenase
What species produces collengenase
P. gingivalis
What type of Collagen is in the gingiva
Type I
What 4 species directly invade host tissues
Aa
P. gingivalis
F. nucleatum
T. denticola
What is the full name of P. gingivalis?
Porphyromonas gingivalis
What is the morphological description of P. gingivalis?
Gram (-)
Non-motile
Anaerobic
Rod
What do we know about P. gingivalis levels in periodontitis?
Elevated levels
Elevated antibody levels
Why is this called the Keystone Pathogen for Chronic Perio Disease?
Its ability to adhere to pocket epithelial cells
