Perio Lesion 3: Histopathology of Gingival Lesions Flashcards

1
Q

What is another term for an initial gingival lesion?

A

Sub-clinical gingivitis

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2
Q

What is a PMN cell?

A

Polymorphonuclear Leukocyte:

Neutrophil
Eosinophil
Basophil
Mast

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3
Q

What happens to blood vessels during sub-clinical gingivitis?

A

Dilate

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4
Q

What was noticed in relation to PMNs with the initial lesion biopsies?

A

Increased chemotaxis of PMNs

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5
Q

What cell protein was deposited during the initial lesion stage?

A

Fibrin

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6
Q

What tissue protein was lost during the initial lesion stage?

A

Perivascular collagen

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7
Q

What are the predominant cells in the tissue during the initial lesion stage?

A

PMN

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8
Q

During the initial lesion stage what was the most notable clinical finding?

A

Increased crevicular fluid

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9
Q

In general what can be said about the tissue conditions during the early lesion stage?

A

Accentuation of the features of the initial lesion
Vascular proliferation
More PMNs
More collagen loss

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10
Q

What new immune cells presented at the early lesion stage?

A

T-cells
Macrophages
Plasma Cells
Mast Cells

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11
Q

Which stage made the rete pegs or ridges pertinent?

A

Early lesion

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12
Q

What was another observation made on the early lesion biopsies?

A

Atrophy

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13
Q

What were the predominant immune cells during the early lesion stage?

A

T-cells

PMNs

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14
Q

What are the clinical observations during the early lesion stage?

A

Bleeding

erythema

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15
Q

What types of cells are normally in the gingival connective tissue?

A

fibroblasts

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16
Q

What does the infiltration of immune cells do to the structure of the connective tissue?

A

Displace collagen fibers

17
Q

What is another term for established gingival lesions?

A

Chronic gingivitis

18
Q

Describe the blood vessels during the established lesion phase?

A

Engorged and congested

19
Q

What is an explanation for the bluish/red color of gums in the established lesion phase?

A

Impaired venous blood return

20
Q

What is the predominant WBC in the tissue during the established lesion stage?

A

Plasma cells (but continued numbers of T’s and PMNs)

21
Q

What two specific antibodies are present during the established lesion stage?

A

IgG1

IgG3

22
Q

Besides the collagen, what portion of the connective tissue is sustaining damage in the established lesion stage?

A

Ground substance

23
Q

What are the 5 Clinical Presentations of the Established Lesion Phase (CPGEN: Clifton Park is Good ENough)

A

Changes in color/texture/size/bleeding
Proliferation, lateral extension, apical migration of junction epithelium
Gingival swelling (pseudopocket)
Elevated flow of crevicular fluid
No separation of gingival fibers cementum

24
Q

How long does it take for an established lesion to convert to an advanced lesion?

A

It varies, some move quickly, others take years