Perio Lesion 3: Histopathology of Gingival Lesions Flashcards
What is another term for an initial gingival lesion?
Sub-clinical gingivitis
What is a PMN cell?
Polymorphonuclear Leukocyte:
Neutrophil
Eosinophil
Basophil
Mast
What happens to blood vessels during sub-clinical gingivitis?
Dilate
What was noticed in relation to PMNs with the initial lesion biopsies?
Increased chemotaxis of PMNs
What cell protein was deposited during the initial lesion stage?
Fibrin
What tissue protein was lost during the initial lesion stage?
Perivascular collagen
What are the predominant cells in the tissue during the initial lesion stage?
PMN
During the initial lesion stage what was the most notable clinical finding?
Increased crevicular fluid
In general what can be said about the tissue conditions during the early lesion stage?
Accentuation of the features of the initial lesion
Vascular proliferation
More PMNs
More collagen loss
What new immune cells presented at the early lesion stage?
T-cells
Macrophages
Plasma Cells
Mast Cells
Which stage made the rete pegs or ridges pertinent?
Early lesion
What was another observation made on the early lesion biopsies?
Atrophy
What were the predominant immune cells during the early lesion stage?
T-cells
PMNs
What are the clinical observations during the early lesion stage?
Bleeding
erythema
What types of cells are normally in the gingival connective tissue?
fibroblasts
What does the infiltration of immune cells do to the structure of the connective tissue?
Displace collagen fibers
What is another term for established gingival lesions?
Chronic gingivitis
Describe the blood vessels during the established lesion phase?
Engorged and congested
What is an explanation for the bluish/red color of gums in the established lesion phase?
Impaired venous blood return
What is the predominant WBC in the tissue during the established lesion stage?
Plasma cells (but continued numbers of T’s and PMNs)
What two specific antibodies are present during the established lesion stage?
IgG1
IgG3
Besides the collagen, what portion of the connective tissue is sustaining damage in the established lesion stage?
Ground substance
What are the 5 Clinical Presentations of the Established Lesion Phase (CPGEN: Clifton Park is Good ENough)
Changes in color/texture/size/bleeding
Proliferation, lateral extension, apical migration of junction epithelium
Gingival swelling (pseudopocket)
Elevated flow of crevicular fluid
No separation of gingival fibers cementum
How long does it take for an established lesion to convert to an advanced lesion?
It varies, some move quickly, others take years
