Thyroid nodules Flashcards

1
Q

What are thyroid nodules?

A

lumps in thyroid gland different from thyroid tissue

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2
Q

Are thyroid nodules common?

A

yes

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3
Q

When do you feel thyroid nodules?

A
  • on palpitation

- Single or multiple and sometimes form of pre-existing goitre

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4
Q

What are the diffuse causes of goitre?

A
  1. Physiological
  2. Grave’s disease
  3. Hashimoto’s thyroiditis
  4. Subacute thyroiditis
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5
Q

What are the nodular causes of goitre?

A
  1. Multinodular goitre
  2. Adenoma
  3. Carcinoma
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6
Q

What are two different types of thyroid nodules?

A
  1. functional

2. non-functional

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7
Q

What investigations are used for thyroid nodules?

A

TFTs

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8
Q

What are TFTs in functional thyroid nodules?

A
  1. High T3 and T4

2. Low TSH

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9
Q

What are TFTs like in non-functional thyroid nodule?

A

normal or high TSH and normal T3 and T4

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10
Q

What is toxic thyroid adenoma usually associated with?

A
  • hyperthyroidism

- young age

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11
Q

What is the TSH like in toxic thyroid adenoma?

A

normal

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12
Q

How do you treat and scan a toxic thyroid adenoma?

A
  • Usually single large thyroid nodule
    1. Thyroid scan with hot area and suppression of extra nodular thyroid tissue
    2. Treatment: radioactive iodine therapy
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13
Q

What are RF for thyroid cancer?

A
  1. Prior radiation
  2. Fhx
  3. Over 65 or under 30
  4. Voice changes, difficulty breathing or swallowing
  5. Firm or hard on palpation or fixed or during swallowing
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14
Q

What would multiple nodules on a scintrgrapahic scan suggest?

A

toxic multinodualr goitre

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15
Q

How do you treat toxic multinodular goitre?

A

radioiondine therapy

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16
Q

Which type of nodule has a lower risk of cancer?

A

functional

17
Q

What would high risk thyroid US show?

A
  1. solid
  2. hypo
  3. irregular margins
  4. microcalcification
    - FNA is unsure
18
Q

When do you do FNA for thyroid nodules?

A
  1. If >1cm in high or intermediate risk: FNA
  2. If >1.5cm in low risk: FNA
  3. If >2cm in very low risk: FNA
19
Q

What are different types of thyroid cancer?

A
  1. Papillary
  2. Follicular
  3. Medullary
  4. Lymphoma
  5. Anaplastic
20
Q

Which thyroid cancers are differentiated

A
  1. Papillary

2. Follicular

21
Q

Which thyroid cancers are undifferentiated?

A

Anaplastic

22
Q

Which type of thyroid cancer is most common?

A

papillary

23
Q

What are RF for papillary thyroid cancer?

A
  1. Radiation exposure

2. Affects young people

24
Q

What are the buzzwords for papillary thyroid cancer?

A
  1. Psammoma bodies

2. Orphan Anne Nuclei

25
Q

Who does follicular thyroid cancer affect?

A

middle aged women especially

26
Q

What are buzz words for follicular thyroid cancer?

A

Hurthle cells

27
Q

What is Medullary thyroid cancer associated with?

A

MEN2 (?FHx)

28
Q

Who does lymphoma thyroid cancer usually affect?

A
  • More common in females

- Generally occurs after pre-existing Hashimot’s’s thyroiditis

29
Q

Who does anaplastic thyroid cancer affect?

A

Elderly females

30
Q

What are buzz words for anaplastic thyroid cancer?

A
  1. giant cells

2. pleomorphic hyperchromatic nuclei

31
Q

What are differential diagnosis for thyroid nodules?

A
  1. Colloid nodule
  2. Thyroid adenoma
  3. Non-toxic multinodular goitre
  4. Thyroid cancer
32
Q

What investigations do you do for thyroid nodules?

A
  1. TSH levels

2. Thyroid US

33
Q

How do you treat follicular and papillary thyroid cancer?

A

-Surgical removal
-After total thyroidectomy:
High risk: Radioiodine therpay and lifelong suppression with T4

34
Q

How do you treat medullary thyroid cancer?

A

Always totally thyroidectomy

35
Q

How do you treat anaplastic thyroid cancer?

A
  • complete thyroidectomy
  • chemotherpay
  • radiotherapy