thyroid hormone Flashcards
hypothalamus produces
Thyrotropin-releasing hormones
pituitary secretes
Thyroid Stimulating Hormone
Thyroid gland produces
Thyroxine
largest endocrine gland
thyroid hormone
calcitonin is secreted by____ cells
parafollicular C cells
calcitonin inhibits _____ and prmotes ______
ihibits bone resoprtion, promotes bone formation
calcitonin is secreted when _____ rises
blood calcium
Thyroid hormone functions
regulate body metabolism, neurologic development, tissue growth, sexual maturation
colloid is rich in ______ and is main storage site of ______
thyroglobulin, thyroid hormones
formation of thyroid hormones
- follicular cell synthesizes enzymes and thyroglobulin
- 1-is co-transported into cell with Na+
- Enzyme (TPO) adds iodine to thyroglobulin making MIT/DIT residues to form T3 and T4
- When stimulated by TSH, thyroglobulin is taken back into cell
- Enzymes separate T3 and T4 from protein
- Free T3/T4 enter circulation
amino acid derived hormone from tyrosine
T4 aka Thyroxine
T4 is a precursor to
T3
T4 reference range
Males: 4.6-10.5 ug/dL
Females: 5.5-11.0 ug/dL
Most active thyroid hormone
T3
T3 is affected by variations in _____
thyroxine binding globulin (TBG)