Thyroid Antagonists Flashcards
What drugs are used for inhibiting the uptake of iodine?
what are they used for?
Perchlorate
Thiocyanate
to diagnose hyperthyroidism
what drugs are used to inhibit the organification step in the thyroid?
methimazole
propylthiouracil
what drugs are used to inhibit the oxidation and iodination of thioamides?
methimazole
propylthiouracil
which drugs can be used to block the synthesis of T3 and T4?
methimazole
propylthiouracil
will methimazole and propylthiouracil inhibit the release of T3 and T4?
no, only the synthesis
how does methimazole inhibit the synthesis of T3 and T4?
by inhibiting thyroid peroxidase and blocking iodine oxidation and the coupling of MIT and DIT
how does propylthiouracil inhibit the synthesis of T3 and T4?
it inhibits the peripheral conversion fo T3 and T4
which do you use in pregnant women, methimazole or propylthiouracil?
why?
propylthiouracil, because it is highly protein bound
what will you see with methimazole toxicity?
pruritic rash
agranulocytosis
what will you see with propylthiouracil toxicity?
pruritic rash adn GI issues
What drugs inhibit the secretion fo T4 and T3?
iodides
iodine
how does iodide inhibit the secretion of T3 and T4?
by inhibiting Thyroid hormone release from the thyroid follicular cells
for what condition is iodide used?
thyroid storm
what will you see with iodide toxicity?
iodism: rash, rhinorrhea, mouth ulcer
what drugs inhibit the conversion of T3 and T4?
propanolol
propylthiouracil
glucocorticoids
when is propranolol used?
in thyroid storm in order to control the cardiac manifestations
when is propylthiouracil used?
thyroid storm
when are glucocorticoids used?
in thyroid storm in order to protect from shock
why would you use radioactive iodine?
what does it do?
what can it lead to?
as an alternative to thyroidectomy
emit beta radiation and destroy thyroid gland
hypothyroidism
what is the treatment for thyroid storm?
propylthiouracil- to inhibit peripheral conversion
propanolol - to stop cardiac manifestations
potassium iodide - inhibit release of thyroid hormones
glucocorticoids - protection from shock
what are the Thioamides?
methimazole
propylthiouracil
