Anti-depressants

Question 1

name the SSRI

Answer 1

1. Fluoxetine
2. Fluvoxamine
3. Paroxetine
4. Citalopram
5. Escitalopram

Question 2

how do SSRI’s work?

Answer 2

they block the reuptake of serotonin

Block SERT

Question 3

what is the active metabolite of fluoxetine?

why is it important?

Answer 3

norfluoxetine

because norfluoxetine has a long half life, therefore, you have to wait 1 month until you may give a MAO-Inhibitor

Question 4

what happens if you give a MAO-I and fluoxetine at the same time?

Answer 4

serotonin syndrome

(rigidity, tremor, diarrhea, hallucinations)

Question 5

Name 2 SSRI’s that are CYP 2D6 inhibitors

Answer 5

fluoxetine and paroxetin

Question 6

name a SSRI that is a CYP 3A4 inhibitor

Answer 6

Fluvoxamine

Question 7

which SSRI’s will have the least amount of side effects?

Answer 7

citalopram and escitalopram

Question 8

what is the main reason ppl will not take their SSRI’s?

Answer 8

because they get sexual dysfunction

Question 9

what are the side effects of paroxetine?

Answer 9

weight gain, diarrhea and nausea

Question 10

what is the difference between TCA’s and SNRI’s?

Answer 10

they both will inhibit SERT and NET, but, TCA’s will also inhibit:

(MAH)

• Muscarinic receptors
• Alpha-1 receptors
• Histamine receptors

Question 11

what are the SNRI’s?

Answer 11

Venlafaxine

Desvenlafaxine

Duloxetin

Question 12

how do SNRI’s work?

Answer 12

they inhibit SERT and NET

Question 13

which category of drugs will be favored in major depressive disorder?

SSRI

SNRI

TCA

SRB

Answer 13

SNRI’s because they have less side effects than TCA’s

Question 14

what are the TCA’s?

Answer 14

Amitriptyline

Protriptyline

Nortriptyline

Desipramine

Imipramine

Trimipramine

Clomipramine

Question 15

what TCA will bind more to SERT?

Answer 15

clomipramine

Question 16

which TCA will be used for the treatment of OCD?

Answer 16

Clomipramine

Question 17

TCA’s will have side-effects depending on the receptor they block..say the side effects for each:

Alpha-1 blocker

Histamine blocker

Muscarinic blocker

Answer 17

1. Alpha-1 blocker: orthostatic hypotension, torsades de pointes
2. Histamine blocker: weight gain
3. Muscarinic blocker: dry mouth, constipation, urinary hesitancy

Question 18

what happens if you overdose on TCA’s?

what do you give as treatment?

Answer 18

coma convulsions and arrhytmias

Sodium Bicarbonate

Question 19

Name a Serotonin receptor blocker

Answer 19

Trazadone

Nafazodone

Question 20

how do serotonin receptor blockers?

Answer 20

block 5-HT-2 receptors

Question 21

what is important to remmeber about trazadone?

Answer 21

it will block 5-HT-2A and 5-HT-2C receptors

Question 22

name a serotonin receptor blocker that is a CYP 3A4 inhibitor

Answer 22

nefazodone

Question 23

Name the tretracyclic and unicyclic antidepressants

Answer 23

bupropion

mirtazapine

amoxapine

maprotiline

Question 24

which Atypical (tetracyclic and unicyclic) antidepressant will increase the activity of NE and DA?

Answer 24

bupropion

Question 25

which atypical antidepressant is used for smoking cessation?

Answer 25

bupropion

Question 26

which atypical antidepressant is contraindicated in epilepsy?

Answer 26

bupropion

Question 27

which atypical antidepressant will be an antagonist of presynaptic alpha 2 receptor?

Answer 27

mirtazapine

Question 28

Name the MAO-Inhibitors that are non-selective

Answer 28

1. Phenelzine 2. Tranylcypromine

Question 29

what are the side effects of MAO-Inhibitors?

Answer 29

cheese effect in foods with tyramine serotonin syndrome if given with SSRI