Thyroditis

Question 1

4 main types of thyroiditis?

Answer 1

Hashimoto
Granulomatous
Subacute lymphocytic
Reidel

Question 2

Hashimoto thyroiditis is the most common cause of what?

Answer 2

Hypo in areas of the world where iodide is sufficient

Question 3

Explain the patho of hashimoto thyroiditis?

Answer 3

Autoantibodies against thyroglobulin and TPO.

Question 4

2 classic histo features diagnostic of hashimoto?

Answer 4

Lymphocyte infiltrate with germinal centers and atrophic follicles with eosinophilic change called hurthle cells

Question 5

Big picture, what is going on with hashitoxicosis?

Answer 5

Immune mediated assault which leads to hyperactivity which exhausts the follicular cells.

Question 6

What are the 3 mechanism of attack they think is going on with hashimoto?

Answer 6

Cd8, macros, and autoantibody.

Question 7

What does a typical thyroid gland look like with hashimoto?

Answer 7

Diffusely enlarged.

Question 8

2 things to remember about granulomatous thyroiditis?

Answer 8

Most common cause of a painful thyroid

They think its origin is found in viral infections

Question 9

2 things to remember about riedels thyroiditis?

Answer 9

Fibrosis and plasma cells producing IG4

Question 10

What are 2 other diseases she wants us to know that are IG4 related?

Answer 10

Idiopathic retroperitoneal fibrosis and autoimmune pancreatitis

Question 11

3 things to remember about subacute lymphocytic thyroiditis?

Answer 11

Painless, postpartum thyroiditis, and autoantibodies are against TPO

Question 12

What is the thyroid state of subacute and granulomatous?

Answer 12

Can be hypo or hyper