Pancreatic NE Tumors

Question 1

What is the gross appearance of these tumors and where do they like to reside in the pancreas most often?

Answer 1

Solid, tan/yellow

Neck and tail

Question 2

most common clinical symptom of an insulinoma? What is the common histo finding of it?

Answer 2

Hypoglycemia

Amyloid deposit

Question 3

3 lab levels to diagnose an insulinoma?

Answer 3

Low glucose, high insulin and c peptide

Question 4

Triad to gastrinoma or zollinger Ellison syndrome?

Answer 4

Islet cell tumor, tons of gastrin, and peptic ulcer

Question 5

What is a clue to clinical diagnosis of a gastrinoma?

Answer 5

Ulcers do not respond to conventional therapy

Question 6

Which NE tumor has gallstones associated?

Answer 6

Somatostinoma

Question 7

What is a characteristic clinical sign of a glucagonoma?

Answer 7

Necrolytic migratory erythema on legs.

Question 8

What are the 4 D’s of a glucagonoma?

Answer 8

Diabetes, dermatitis, depression and DVTs

Question 9

3 clinical signs of a VIPoma?

Answer 9

Water diarrhea, hypokalemia, and achlorhydria

Question 10

Which 2 NE tumors have 80% metastatic rates?

Answer 10

Somatostatinomas and VIPomas

Question 11

What are the most common pancreatic endocrine neoplasms?

Answer 11

Insulinoma

Question 12

Which two NE tumors have 60% metastatic rates?

Answer 12

Gastrinoma and glucagonoma

Question 13

What can be a common symptom and, 30% of the time, the presenting symptom with Zollinger Ellison syndrome?

Answer 13

Diarrhea