Normal Thyroid She Wants Us To Know

Question 1

Explain how we get thyroid hormone into circulation and the major players involved? What is the big picture net effect?

Answer 1

Hypothalamus is simulated to release TRH to activate the pituitary to stimulate the release of TSH. TSH heads down to the thyroid gland to stimulate the release of thyroid hormone. Thyroid hormone is released in the form of mostly T4 and a little T3. At the tissue level, T$ is converted into T3 because of its higher affinity for thyroid receptors. Net effect, increase metabolic rate.

Question 2

How is T4 converted to T3?

Answer 2

Deiodinated

Question 3

Explain what a goitrogen is?

Answer 3

This is the term given to any chemical that inhibits the thyroid gland is any way

Question 4

What are the two ways propythiouracil inhibits thyroid hormones?

Answer 4

Block the oxidation of iodide which is responsible for the synthesis of thyroid hormones.
Blocks the peripheral deiodination of t4 to t3.

Question 5

What is another name for parafollicular cells and what are they responsible for?

Answer 5

C cells. Secrete calcitonin to take calcium out of blood and put it in blood. Lower blood calcium.

Question 6

Diseases of the thyroid include conditions associated with what 3 situations?

Answer 6

Too much thyroid hormone, not enough and mass lesions.