Thrombophilia screening Flashcards
1
Q
Inherited;
APC resistance/ ? ? ? mutation.
Antithrombin ? deficiency.
? gene mutation.
A
factor v leiden
3
prothrombin
2
Q
Acquired;
??? syndrome.
A
APL
3
Q
Indications for screening
Arterial thrombosis Venous thrombosis with no risk factors. ? VTE ? ? VTE Unusual site of thrombosis - ? or ? vein thrombosis Recurrent ? loss
A
50 40 familial recurrent unexplained mesenteric portal foetal
4
Q
Ix
?.
?.
? concentration+/- ? resistance test.
? anticoagulant/ anti ?-? antibodies
A
fbc clotting plasminogen APC lupus cardio-lipin
5
Q
Ix
? and Protein ?/? assays for deficiency.
? ? ? mutation ? if APC resistance test is ?.
PCR for ? gene mutation.
A
antithrombin c/s factor v leiden pcr positive prothrombin
